Peak Oxygen Uptake and Cardiovascular Risk Factors in 4631 Healthy Women and Men

Aspenes, Stian Thoresen; Nilsen, Tom Ivar Lund; Skaug, Eli-Anne; Bertheussen, Gro F.; Ellingsen, Øyvind; Vatten, Lars J.; Wisløff, Ulrik

doi:10.1249/mss.0b013e31820ca81c

Cited by 240 publications

(258 citation statements)

References 38 publications

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“…8 In this context, we find that the CON VO2max (~40 ml kg -1 min -1 ) is similar to the average VO2max of healthy men and women with similar age as our participants (i.e. ~41 ml kg -1 min -1 ).…”

Section: Validity Of the Walking Protocolsupporting

confidence: 80%

“…a "gold standard" VO2max test). If the walking protocol and the running protocol result in similar VO2max values in able-bodied subjects, and objective criteria for achieving VO2max are satisfied 8 , one may assume that the incremental walking test is a valid test protocol for measuring VO2max. Given this, the walking protocol will unquestionably generate sufficient physiological stress to generate VO2max in transfemoral amputees.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of aerobic capacity and walking economy of unilateral transfemoral amputees

Gjøvaag¹,

Starholm²,

Mirtaheri³

et al. 2014

Prosthetics &Amp; Orthotics International

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Background; Studies of the maximal oxygen uptake (VO2max) of transfemoral amputees (TFA) have mostly used protocols that activate a relatively small muscle mass. Consequently, TFA VO2max may be systematically underestimated, and the validity of these test protocols is questionable.Objectives; 1) Investigate validity and reliability of a VO2max walking protocol. 2) Compare the VO2max of a TFA group to a group of matching controls (CON).Study design; 1) Randomized crossover study; walking vs. running VO2max for the CON group, 2) case-control study; TFA vs. CON group VO2max.Methods; Twelve TFA and CON participants performed a walking VO2max test with increasing treadmill inclinations to voluntary exhaustion. The CON group also completed a running ("gold-standard") VO2max test.Results; Mean (SD) CON group VO2max following walking and running was similar, i.e. 2.99 (0.6) and 3.09 (0.7) L·min -1 , respectively. Mean (SD) TFA walking VO2max was 2.14 (0.8) L·min -1 (compared to CON; p < 0.01). Mean intra-class correlation coefficient (ICC) of repeated VO2 measurements was 0.97, and within-subjects standard deviation (Sw) was 60 mL min -1 . Conclusions;The walk protocol is valid. Walking VO2max of TFA was 40 % lower compared to CON.Reliability of the walking protocol is comparable to other walking protocols. Word count: 200 Clinical relevanceThe design, alignment and materials of prostheses are important for effective ambulation. Cardiorespiratory fitness is, however, also important in this regard, and a low fitness may compromise health and independent living. Hence, TFA with low physical fitness should engage in regular physical activity to improve health, gait capacity and independency.Word count: 50

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Section: Validity Of the Walking Protocolsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Assessment of aerobic capacity and walking economy of unilateral transfemoral amputees

Gjøvaag¹,

Starholm²,

Mirtaheri³

et al. 2014

Prosthetics &Amp; Orthotics International

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“…De fato, estudos prévios demonstraram, de maneira sistemática, que a aptidão cardiorrespiratória é inversamente relacionada com a pressão arterial e perfil lipídico (25), sendo esse um importante e independente preditor de risco cardiovascular (26). Além disso, um estudo mostrou que um decréscimo de 5% no VO 2 max resulta em 56% de incremento no risco cardiovascular (27). Por outro lado, cada 1 ml/kg/min de incremento no VO 2 max resulta em uma diminuição de aproximadamente 15% no risco de morte por todas as causas (28).…”

Section: Associação Entre Genótipo Glu298asp +-786t>c E Aptidão Cardiunclassified

Prevalência de dislipidemia em adultos de meia-idade com polimorfismo do gene NOS3 e baixa aptidão cardiorrespiratória

Malagrino

Sponton

Esposti

et al. 2013

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Analisar a influência da associação dos polimorfismos do gene da sintase do óxi-do nítrico endotelial (NOS3) para as posições -786T>C, Glu298Asp e íntron 4b/a e a aptidão cardiorrespiratória sobre as concentrações de nitrito/nitrato, pressão arterial, perfil lipídico e prevalência de doenças cardiometabólicas em adultos. Sujeitos e métodos: Noventa e duas pessoas foram divididas de acordo com o genótipo: não polimórficas (NP) e polimórficas (P). Posteriormente, foram subdivididas pela aptidão cardiorrespiratória associada ao genó-tipo: alta (ANP e AP) ou baixa (BNP e BP). Resultados: Os indivíduos que apresentavam polimorfismo para as posições Glu298Asp+Íntron 4b/a e Glu298Asp+-786T>C e baixa aptidão cardiorrespiratória apresentaram maiores valores de colesterol total e maior prevalência de dislipidemia. Conclusão: Nossos dados demonstram que os polimorfismos do gene da NOS3 para essas duas associações influenciam os níveis de colesterol plasmático, e essa associação foi mais claramente observada quando os indivíduos apresentavam menor nível de aptidão cardiorrespiratória. Arq Bras Endocrinol Metab. 2013;57(1):33-43 Descritores Polimorfismos; aptidão cardiorrespiratória; dislipidemia; adultos ABSTRACT Objective: To evaluate the influence of the interaction between endothelial nitric oxide synthase gene (NOS3) polymorphisms at positions -786T>C, Glu298Asp and intron 4b/a, and cardiorespiratory fitness on plasma nitrite/nitrate levels, blood pressure, lipid profile, and prevalence of cardiometabolic disorders. Subjects and methods: Ninety-two volunteers were genotyped for NOS3 polymorphisms at positions (-786T>C and Glu298Asp) and (intron 4b/a) and divided according to the genotype: non-polymorphic (NP) and polymorphic (P). After that, they were subdivided according to the cardiorespiratory fitness associated with genotype: high (HNP and HP) and low (LNP and LP). Results: The subjects with polymorphism for the interactions at positions Glu298Asp + intron 4b/a, and Glu298Asp+-786T>C showed the highest values in total cholesterol, as well as dyslipidemia. Conclusion: Our findings show that NOS3 gene polymorphisms at positions -786T>C, Glu298Asp, and intron 4b/a exert negative effects on the lipid profile compared with those who do not carry polymorphisms. Arq Bras Endocrinol Metab. 2013;57(1):33-43

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“…I en metaanalyse som ble validert i et uavhengig utvalg med over 500 friske individer kom man frem til regresjonsformelen: HR maks = 208  0,7  alder (6). I Helseundersøkelsen i Nord-Trøndelag (HUNT) testet vi maksimal hjertefrekvens hos 3 320 friske personer (7,8). Dette er den største enkeltundersøkelse av belastning og kondisjon til dags dato.…”

Section: Ulike Formlerunclassified

Maksimal forventet hjertefrekvens

Støylen¹,

Nes²,

Karlsen³

2012

Tidsskriftet

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Peak Oxygen Uptake and Cardiovascular Risk Factors in 4631 Healthy Women and Men

Abstract: These data represent the largest reference material of objectively measured VO2peak in healthy men and women age 20-90 yr. Even in people considered to be fit, VO2peak was clearly associated with levels of conventional cardiovascular risk factors.

Cited by 240 publications

References 38 publications

Assessment of aerobic capacity and walking economy of unilateral transfemoral amputees

Assessment of aerobic capacity and walking economy of unilateral transfemoral amputees

Prevalência de dislipidemia em adultos de meia-idade com polimorfismo do gene NOS3 e baixa aptidão cardiorrespiratória

Maksimal forventet hjertefrekvens

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