Peak inspiratory flow evaluation in different stages' COPD patients using in-check method (INSPIRE STUDY)

Ζervas, Εleftherios; Petrocheilou, Kalomoira; Tsopa, Paschalina; Evangeliou, Mina; Athanassiou, Aikaterini

doi:10.1183/13993003.congress-2016.pa3962

Cited by 2 publications

(2 citation statements)

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“…The In-Check Dial ® (Clement Clarke International, Harlow, UK) allows the simulation of different intrinsic resistances and directly evaluates different inhalers at the patient's bedside [44]. It has been shown to have excellent reproducibility and a good correlation with PIF derived from spirometry [39,42,43,45] and is increasingly recognized as an easy and fast way to evaluate PIF [46][47][48][49]. Different studies show a good correlation between low handgrip strength and weak PIF, which may serve as a surrogate to estimate PIF [23,[50][51][52][53].…”

Section: Peak Inspiratory Flowmentioning

confidence: 99%

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Renaud,

Suter,

Grandmaison

2023

Respiration

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Inhaler misuse is common among patients with chronic obstructive pulmonary disease and associated with poor disease control. Many patient characteristics are reported to impact inhaler use, but there are no studies in the literature on the best way to evaluate them. This narrative review aims to identify patient characteristics that influence the correct use of an inhaler and describe the tools available for their assessment. First, we searched four different databases to identify reviews describing patient characteristics reported to impact inhaler use. In a second step, ways to characterize these aspects were searched using the same databases. Fifteen patient characteristics impacting on the use of inhalers were identified. Peak inspiratory flow, dexterity, and cognitive impairment were the most studied characteristics and appeared to have the highest impact on the correct use of inhalers. Notably, peak inspiratory flow can be reliably assessed in clinical practice using the In-Check Dial<sup>®</sup>. Triggering coordination, breath retention, collaboration/consciousness, and muscle strength in the fingers were important characteristics, but insufficient data exist to recommend the use of a specific tool for their assessment in daily practice. Other identified characteristics have a more uncertain impact. A demonstration of inhalation technique by the patient, combined with the measurement of peak inspiratory flow using the In-Check Dial<sup>®</sup>, appears to be an effective strategy to assess the characteristics with the highest impact on the correct use of an inhaler. In the future, “smart” inhalers could also play a decisive role in this area.

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Section: Peak Inspiratory Flowmentioning

confidence: 99%

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Renaud,

Suter,

Grandmaison

2023

Respiration

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“…The Accuhaler, Clickhaler, Turbohaler, and Rotahaler are devices offering medium resistance, whereas high-resistance devices include the Handihaler and Easyhaler. Patients with COPD have compromised lung functions [ 11 , 13 , 14 ]. Therefore, an intricate balance between inspiratory flow rate and device resistance must be considered to achieve the desired aerosol performance.…”

Section: Introductionmentioning

confidence: 99%

Roflumilast Powders for Chronic Obstructive Pulmonary Disease: Formulation Design and the Influence of Device, Inhalation Flow Rate, and Storage Relative Humidity on Aerosolization

et al. 2021

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Roflumilast is currently administered orally to control acute exacerbations in chronic obstructive pulmonary disease (COPD). However, side effects such as gastrointestinal disturbance and weight loss have limited its application. This work aimed to develop an inhalable roflumilast formulation to reduce the dose and potentially circumvent the associated toxicity. Roflumilast was cospray-dried with trehalose and L-leucine with varied feed concentrations and spray-gas flow rates to produce the desired dry powder. A Next-Generation Impactor (NGI) was used to assess the aerosolization efficiency. In addition, different devices (Aerolizer, Rotahaler, and Handihaler) and flow rates were used to investigate their effects on the aerosolization efficiency. A cytotoxicity assay was also performed. The powders produced under optimized conditions were partially amorphous and had low moisture content. The powders showed good dispersibility, as evident by the high emitted dose (>88%) and fine particle fraction (>52%). At all flow rates (≥30 L/min), the Aerolizer offered the best aerosolization. The formulation exhibited stable aerosolization after storage at 25 °C / 15% Relative Humidity (RH) for one month. Moreover, the formulation was non-toxic to alveolar basal epithelial cells. A potential inhalable roflumilast formulation including L-leucine and trehalose has been developed for the treatment of COPD. This study also suggests that the choice of device is crucial to achieve the desired aerosol performance.

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Peak inspiratory flow evaluation in different stages' COPD patients using in-check method (INSPIRE STUDY)

Cited by 2 publications

References 0 publications

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Patient Characteristics to Consider When Selecting an Inhaler for the Treatment of Chronic Obstructive Pulmonary Disease and Available Assessment Methods: A Narrative Review

Roflumilast Powders for Chronic Obstructive Pulmonary Disease: Formulation Design and the Influence of Device, Inhalation Flow Rate, and Storage Relative Humidity on Aerosolization

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