Peak focusing based on stationary phase thickness gradient

Li, Maxwell Wei-Hao; Zhu, H.; Zhou, Menglian; She, Jinyan; Li, Ziqi; Kurabayashi, Katsuo; Fan, Xudong

doi:10.1016/j.chroma.2019.460737

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…Microfabricated GC columns at the University of Michigan began in the laboratory of Richard Sacks . Further developments of microfabricated GC columns have continued in the laboratories of Katsuo Kurabayashi and Xudong Fan. − These systems have extended to different detectors, − multidimensional micro GC–GC systems (two-dimensional (2D) and three-dimensional (3D) systems), microinjectors (preconcentrators), , and micro thermal modulators . We have previously demonstrated the analytical utility of multidimensional gas chromatography for in situ investigations of multiple harsh environments. , In this paper, work focuses on an adaptation for GC–MS of a MEMS micro GC equipped with a 10 m long rectangular (150 μm × 240 μm) analytical column and micro-photoionization detector (μ-PID) at the GC analytical column exit.…”

Section: Introductionmentioning

confidence: 99%

Experimental Coupling of a MEMS Gas Chromatograph and a Mass Spectrometer for Organic Analysis in Space Environments

Libardoni

Miller

et al. 2020

ACS Earth Space Chem.

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The mass spectrometer for planetary exploration (MASPEX) is a versatile mass spectrometer with unprecedented mass resolution designed for spaceflight. However, the current version of MASPEX is designed for continuous sampling during flybys of planetary bodies and does not include gas chromatography, which can improve the analysis of complex mixtures of organic compounds in space environments. Here, micro-electro-mechanical system (MEMS) gas chromatography (GC) linearity, reproducibility, and column analytical performance were first demonstrated prior to the coupling to MASPEX for MEMS GC−mass spectrometer (MS) analyses. Linearity of response was demonstrated for n-hexane over 2 orders of magnitude of on-column mass (concentration). Retention time reproducibility in the MEMS GC was ≤2% relative standard deviation (RSD). MEMS GC column analytical performance calculations showed the average number of theoretical plates, N, and the height equivalent to a theoretical plate, HETP, to be 16 239 (1623 plates per meter) and 0.062 cm, respectively. N defines a chromatographic centroid peak apex divided by the peak width at half height, similar to mass resolution. When coupled to MASPEX, the retention time reproducibility was in a similar range of 1−2% relative standard deviation with a slightly larger deviation seen from the mass spectrometer detector due to start trigger variations with a manual start trigger in the FastFlight software compared to the LabView code used for the MEMS GC−MS testing. The collected mass spectra showed close consistency with National Institute of Standards and Technology (NIST) reference mass spectra providing confidence in chemical compound identification. We present the first data generated from the coupling of these devices.

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Section: Introductionmentioning

confidence: 99%

Experimental Coupling of a MEMS Gas Chromatograph and a Mass Spectrometer for Organic Analysis in Space Environments

Libardoni

Miller

et al. 2020

ACS Earth Space Chem.

Self Cite

View full text Add to dashboard Cite

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“…With these results, the separation of substances can be evaluated via the resolution of neighboring substance peaks in the chromatogram. Such simulations are of interest for method development, especially in multidimensional GC (Gaida et al, 2021;Hou et al, 2018;Jaramillo & Dorman, 2020) and for the evaluation of new techniques, like thermal gradient GC (Leppert, Müller, et al, 2020) or stationary phase thickness gradients (Li et al, 2020). While the presented package only models one-dimensional GC separation, it can be used as the base for a multi-dimensional GC separation.…”

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confidence: 99%

GasChromatographySimulator.jl

Leppert¹

2022

JOSS

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Gas chromatography (GC) is a technique used in analytical chemistry to separate a mixture of vaporizable substances by injecting the mixture into a gas stream (mobile phase), which passes along a tube, called column, of length 𝐿 and diameter 𝑑. The column is coated with a stationary phase of a film thickness 𝑑 𝑓 . The substances of the mixture interact with the stationary phase by partition between mobile and stationary phase, resulting in different effective velocities of the substances. At the end of the column the substances are registered in a detector at different times, called retention times, and with different peak widths, resulting in a chromatogram. GC is used for qualitative and quantitative analysis, e.g. in petrochemistry, food chemistry, environmental analytics, and forensic science.

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Theory of gas chromatography

Blumberg¹

2021

Gas Chromatography

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Peak focusing based on stationary phase thickness gradient

Cited by 6 publications

References 18 publications

Experimental Coupling of a MEMS Gas Chromatograph and a Mass Spectrometer for Organic Analysis in Space Environments

Experimental Coupling of a MEMS Gas Chromatograph and a Mass Spectrometer for Organic Analysis in Space Environments

GasChromatographySimulator.jl

Theory of gas chromatography

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