Peak dispersion and hydrolysis kinetics ofN‐methylcarbamates in packed‐bed and coiled capillary reactors

Abstract

The Chromatographic and kinetic performance of the hydrolysis of some N-methylcarbamates in (glass bead) packed-bed and coiled open capillary reactors is examined, using sodium hydroxide solutions in methanol + water mixtures at about 95°C. The efficiency of the hydrolysis to methylamine in these reactors is evaluated with kinetic in vitro data. Finally, the reaction dispersion in an RP-18/TBA-OH solid-phase reactor is described in terms of a simple model and the utility of this reactor for carbamate hydrolysis is briefly discussed.