Peach tree pollen and Pru p 9 may induce rhinoconjunctivitis and asthma in children†

Sanchez, Natalia Perez; Somoza, María Luisa; Garrido‐Arandia, María; Puche, Laura Victorio; Blanca‐López, Natalia; Haroun‐Díaz, Elisa; Sahagún, Alejandro Romero; Díaz‐Perales, Araceli; Cantó, Gabriela; Blanca, Miguel; Cornejo-García, J.A.

doi:10.1111/pai.13067

Cited by 6 publications

(4 citation statements)

References 8 publications

(10 reference statements)

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“…To our best knowledge, this is the first systematic review and meta‐analysis to comprehensively summarize the relationships between pollen exposure and asthma exacerbation, as assessed through various respiratory outcomes with strict methodological concerns. The existing literature collected in a recent review of the respiratory health burden attributable to short‐term exposure to pollen had already suggested evidence of an association between outdoor pollen concentrations and most of the asthma outcomes we considered, especially in people with pre‐existing respiratory diseases 3–139 . Our overall meta‐analysis, subgroup analysis, and publication bias assessment confirm that a relationship between pollen exposure and asthma exacerbation exists but this require additional research due to its heterogeneity.…”

Section: Discussionsupporting

confidence: 54%

“…Teranishi et al 46 conducted an epidemiological study on pollinosis among Japanese pear orchard workers and found positive skin tests (SPT) in 5.4% of them. Jiang et al 47 described a case of occupational allergy to peach ( Prunus persica ) pollen in an artificial pollination worker. Victorio‐Puche et al 48 reported occupational rhinitis and/or asthma among 21 peach orchard workers, demonstrating SPT‐positive sensitization to this pollen.…”

Section: State Of Artmentioning

confidence: 99%

See 1 more Smart Citation

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Annesi‐Maesano

Cecchi

Biagioni

et al. 2023

Allergy

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Limited number of studies have focused on the impact of pollen exposure on asthma. As a part of the EAACI Guidelines on Environment Science, this first systematic review on the relationship of pollen exposure to asthma exacerbations aimed to bridge this knowledge gap in view of implementing recommendations of prevention. We searched electronic iPubMed, Embase, and Web of Science databases using a set of MeSH terms and related synonyms and identified 73 eligible studies that were included for systemic review. When possible, meta‐analyses were conducted. Overall meta‐analysis suggests that outdoor pollen exposure may have an effect on asthma exacerbation, but caution is needed due to the low number of studies and their heterogeneity. The strongest associations were found between asthma attacks, asthma‐related ED admissions or hospitalizations, and an increase in grass pollen concentration in the previous 2‐day overall in children aged less than 18 years of age. Tree pollen may increase asthma‐related ED visits or admissions lagged up to 7‐day overall in individuals younger than 18 years. Rare data show that among subjects under 18 years of age, an exposure to grass pollen lagged up to 3 days may lower lung function. Further research considering effect modifiers of pollen sensitization, hay fever, asthma, air pollution, green spaces, and pre‐existing medications is urgently warranted to better evaluate the impacts of pollen on asthma exacerbation. Preventive measures in relation to pollen exposure should be integrated in asthma control as pollen increase continues due to climate change.

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Section: Discussionsupporting

confidence: 54%

Section: State Of Artmentioning

confidence: 99%

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Annesi‐Maesano

Cecchi

Biagioni

et al. 2023

Allergy

View full text Add to dashboard Cite

show abstract

“…1 Component diagnosis of peach allergy indicates Pru p 1, Pru p 2, Pru p 3, Pru p 4, Pru p 7, and Pru p 9 are involved. 2,3 Pru p 3 is the dominant allergen responsible for severe allergic reaction, 4 and it is considered to be the primary sensitizer to other LTPs in Mediterranean and Central Europe. 5 The levels of Pru p 3 differ between varieties.…”

Section: Selection Of Pru P 3 Hypoallergenic Peach and Nectarine Varietiesmentioning

confidence: 99%

“…1 Through both constitutive and induced exocytosis, MCs release exosomes that deliver several molecules including mRNA/miRNA 2 and subunits of the high-affinity IgE receptor (FcεRI). 3 However, the role of MC-derived vesicles in the context of allergic reactions is still controversial. A recent study provides evidence that exosomes released from unstimulated mouse bone marrow-derived mast cells (mBMMCs) bind to free IgE and decrease circulating IgE levels, thus inhibiting the allergic response.…”

Section: Immune Complexes Exposed On Mast Cell-derived Nanovesicles Amplify Allergic Inflammationmentioning

confidence: 99%

Selection of Pru p 3 hypoallergenic peach and nectarine varieties

Jin

Gao

Zhao

et al. 2019

Allergy

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Prunus persica9, a new occupational allergen from peach tree pollen involved in rhinitis and asthma

et al. 2020

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ObjectivesSeveral studies have described peach tree (PT) as an occupational allergen. The aim of this work was to assess the effect of Prunus persica 9 (Pru p 9), a recently identified allergen from PT pollen, in exposed workers.MethodsThe study included people who reported respiratory symptoms after handling PT in orchards during the flowering period (Blanca village, Murcia region, south-east Spain). After completing a detailed questionnaire, participants underwent skin prick test (SPT) and nasal provocation test (NPT). The IgE response was analysed by SDS-PAGE and immunoblotting assays.ResultsA total of 21 cases were included (mean age 45 years; 57% women). Most were polysensitised to common pollens, although one person was sensitised only to PT pollen. All cases had a positive SPT to this pollen, and 43% also to Pru p 9. All participants reported having rhinitis, and six participants reported having also asthma. Immunoblotting showed a heterogeneous IgE pattern for several proteins, with Pru p 9 recognised in nine cases. Most participants sensitised to PT pollen and Pru p 9 had positive NPTs, while those who were not sensitised to Pru p 9 tested negative.ConclusionsWe demonstrate for the first time that Pru p 9, an allergen from PT pollen, can induce respiratory symptoms following occupational exposure. This must be considered a relevant allergen when people working with PT cultivars develop respiratory symptoms.

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Peach tree pollen and Pru p 9 may induce rhinoconjunctivitis and asthma in children†

Cited by 6 publications

References 8 publications

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Selection of Pru p 3 hypoallergenic peach and nectarine varieties

Prunus persica9, a new occupational allergen from peach tree pollen involved in rhinitis and asthma

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