Peach allergy in spanish children: tolerance to the pulp and molecular sensitization profile

Boyano-Martínez, Teresa; Pedrosa, María; Belver, Teresa; Quirce, Santiago; García-Ara, Carmen

doi:10.1111/pai.12037

Cited by 36 publications

(44 citation statements)

References 20 publications

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“…Prevalence data on allergen‐specific sensitization have been generated by a few European wide studies. For apple the SAFE study provided data on Mal d 1–Mal d 4 , while the peach allergens were investigated in Spanish and Italian studies reflecting the clear‐cut difference in the frequency of LTP sensitization predominant in the southern European areas as compared to the PR‐10 sensitization detected in areas with Fagales pollen exposure. Several kiwifruit studies were performed including a multicenter, within the EuroPrevall project and single center studies (Table ).…”

Section: Sensitization To Individual Molecules and Their Clinical Relmentioning

confidence: 99%

“…To date limited components are available to facilitate the in vitro diagnosis in fruit and vegetable allergies . This comprises cross‐reactive allergens derived from inhalant allergenic sources (Bet v 1 and Bet v 2 from birch pollen and the latex allergens Hev b 6.01, 6.02, and 11) as well as food components from few Rosaceae fruits (Mal d 1, 3; Pru p 1, 3, 4) , kiwifruit allergens (Act d 1, 2, 5, 8) and some Apiaceae allergens (Dau c 1, Api g 1). The following section therefore concentrates on Rosaceae, Apiaceae, kiwifruit allergy, and the latex‐fruit syndrome.…”

Section: Clinical Relevance Diagnosis and Managementmentioning

confidence: 99%

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EAACI Molecular Allergology User's Guide

Matricardi

Kleine-Tebbe²,

Hoffmann

et al. 2016

Pediatric Allergy Immunology

724

870

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The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

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Section: Sensitization To Individual Molecules and Their Clinical Relmentioning

confidence: 99%

Section: Clinical Relevance Diagnosis and Managementmentioning

confidence: 99%

EAACI Molecular Allergology User's Guide

Matricardi

Kleine-Tebbe²,

Hoffmann

et al. 2016

Pediatric Allergy Immunology

724

870

View full text Add to dashboard Cite

show abstract

“…Sensitization to LTP from both fruits [24, 25] and tree nuts [25] is high in the Mediterranean area, as was recently shown for hazelnut in the EuroPrevall study [26]. LTP sensitization is frequently associated with severe systemic reactions [25].…”

Section: Discussionmentioning

confidence: 99%

Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach

Silva

Vieira

Pereira

et al. 2016

Clin Transl Allergy

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BackgroundChallenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and an allergen microarray test in the identification of IgE-mediated cross-reactive food allergens in patients with suspected FDEIA or food-dependent exercise-induced urticaria and panallergen sensitization.MethodsThree patients with a history of food dependent exercise induced urticaria/anaphylaxis and food panallergen sensitization in whom a food-exercise challenge was not feasible were selected: a 25-year-old man with cholinergic urticaria who experienced generalized urticaria and angioedema during a soccer match after drinking a peach-based soft drink; a 19-year-old woman with allergic rhinitis and controlled asthma who experienced anaphylactic shock while playing soccer, having eaten walnuts in the previous 90 min; and a 57-year-old man with baker’s asthma who experienced four episodes of anaphylaxis during exercise after ingesting wheat-containing food. All individuals underwent a diagnostic work-up with skin prick tests, specific IgE (sIgE) and ImmunoCAP ISAC test. For the in vitro immunodepletion procedure, patients’ serum was pre-incubated with the suspected native allergen (peach, walnut, or wheat) in solid phase (ImmunoCAP). The eluted serum, containing unbound IgE, was collected and samples were re-tested using Immunocap ISAC 112 and compared with baseline results.ResultsAll individuals were sensitized to lipid transfer proteins. The first patient was sensitized to Pru p 3, Cor a 8, Jug r 3, and Ara h 9; after pre-incubation with peach there was 100% depletion of sIgE to all components. The second patient was sensitized to Pru p 3, Cor a 8, Jug r 3, and Ara h 9; immunodepletion with walnut depleted sIgE to Ara h 9 by 67%, Pru p 3 and Pla a 3 (60%), Art v 3 (75%), Jug r 3 (88%), and Cor a 8 (100%). The third patient was sensitized to Pru p 3, Jug r 3, Ara h 9, and Tri a 14; immunodepletion with wheat depleted Tri a 14 only (100%).ConclusionsIn vitro immunodepletion might be a useful diagnostic tool in food dependent exercise induced urticaria/anaphylaxis with panallergen sensitization, particularly for identifying the culprit allergen and guiding dietary elimination recommendations.

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“…They are polypeptides that are widely found in the plant kingdom and are implicated in the defence against pathogens (PR-14). 21 Until recently, melon allergy was mainly considered to be a marker of profilin hypersensitivity, as the only reactions described were related to melon-pulp ingestion, and almost all the reactions were mild. The high rate of sensitization to vegetables in the Mediterranean area can be explained by sensitization to panallergens (profilin and LTP) and the high degree of cross-reactivity between each of these proteins.…”

Section: Discussionmentioning

confidence: 99%