PDZ Domains: Intracellular Mediators of Carboxy‐Terminal Protein Recognition and Scaffolding

Abstract

Originally published in: Modular Protein Domains. Edited by Giovanni Cesareni, Mario Gimona, Marius Sudol and Michael Yaffe. Copyright © 2005 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3‐527‐30813‐2 The sections in this article are Introdution Structural Analysis of PDZ Domains Analysis of PDZ Domain–Ligand Interactions with Mutagenesis and Synthetic Peptides Molecular and Signaling Functions of PDZ Domains INAD as a Molecular Scaffold LIN‐7‐Receptor Tyrosine Kinase Interactions and Subcellular Localization PDZ Domain Proteins and Epithelial Polarity Induction and Maintenance A Few Miscellaneous Examples: The Synapse, Disheveled, CARD MAGUKs, and Beta Adrenergic Receptors Conclusions Acknowledgements