PDR for Herbal Medicines

Marty, André

doi:10.1001/jama.281.19.1853

Cited by 13 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, preparations of hawthorn are available in various forms ranging from infusions and tinctures to standardized extracts and may be available variously as authorized prescription drugs, over-the-counter (OTC) medications, authorized herbal medicinal products, dietary supplements, or unregulated herbal remedies. The use of hawthorn for the treatment of cardiovascular heart disease dates back to the late 1800s [ 6 , 7 ]. Current claims suggested that hawthorn could be used as an alternative therapy for various cardiovascular diseases, such as angina, hypertension, hyperlipidemia, arrhythmia, and New York Heart Association (NYHA) functional class II congestive heart failure [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…10 Previous phytochemical analysis of Fumaria officinalis has shown the presence of alkaloids such as protopine, cryptopine, stylopine, N-methylsinactine, fumaritine, fumariline, sanguinarine and polyphenols such as rutin and apigenin. 11,12 Fumaria has been traditionally used for the treatment of rashes, fever, diarrhea, syphilis, and leprosy, 13 also has aphrodisiac activity 14 as well diuretic, depurative, anti-inflammatory, antiarrhythmic, antioxidant and antimicrobial activities. 15 The therapeutic effect of different Fumaria species for male infertility has been mentioned, 16 but none was Fumaria officinalis included.…”

Section: Plant Materialsmentioning

confidence: 99%

The protective effect of Fumaria officinalis against the testicular toxicity of fluoxetine in rat

2020

View full text Add to dashboard Cite

Background and objective: Extracts of Fumaria species have been traditionally used for the treatment of some skin diseases, rheumatism, stomach ache, fever, and male infertility mainly because of the presence of isoquinoline alkaloids. On the other side, fluoxetine is used as an antidepressant induce sexual dysfunction and a decrease in sperm concentration, motility, and morphology. The present investigation dealt with the study of the protective role played by the Fumaria officinalis extract against the selective serotonin reuptake inhibitor (SSRI) induced testicular toxicity in the rat. Therefore, the purpose of this work was to determine the benefits of Fumaria officinalis extract in animals treated with fluoxetine. Methods: Thirty six male rats were divided into three following groups, control group, fluoxetine (20 mg/kg/day) treated-group, and the same dose of Fluoxetine plus Fumaria officinalis extract (150 mg/kg/day) as a third group. Drugs and extract were administered orally for 30 days. Sections of testes were stained by Haematoxylin and Eosin.Results: Fluoxetine has caused several structural changes in the rat testis such as vacuolation within germinal epithelium of seminiferous tubules, decrease the diameter of these tubules and decrease number of sertoli and germinal cells. Treating the fluoxetine exposed rats with Fumaria officinalis extract has shown to ameliorate the above histological changes. Conclusion: Fumaria officinalis extract can protect testis from histological alterations caused by the toxicity of the fluoxetine.

show abstract

“…Hypericum species L. (Hypericaceae) are wellknown for their various medicinal properties due to the presence of active compounds, such as: hypericin, pseudohypericin (naphtodianthrones); hyperforin, adhyperforin (phloroglucinol derivatives); hyperoside, rutin, quercetin, quercitrin (flavonoids); essential oil; tannins [8]. Twelve Hypericum sp.…”

Section: Introductionmentioning

confidence: 99%

“…are mentioned in the Romanian spontaneous flora, while worldwide there are more than 480, known as healing herbs due to their therapeutic properties [5,15,16]. The most important species of the genus is considered H. perforatum L. (St. John's wort), which has been used in the treatment of mild to moderate depression for its antidepressant effects, and also as antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant or externally to treat skin wounds, eczema, burns [1,8,14]. Several studies indicated the variations in quality and quantity of active compounds, with significant differences between species, between populations from different areas, and between different ontogenetic phases of the same individual [5,14].…”

Section: Introductionmentioning

confidence: 99%

Comparative Phytochemical Profile of Hypericum Perforatum and Hypericum Hirsutum (Hypericaceae)

ONIGA¹

2022

FARMACIA

View full text Add to dashboard Cite

The present research focused on comparative phytochemical analysis of Hypericum perforatum and H. hirsutum aerial parts harvested from different areas of Transylvania (Romania). Total flavonoids and total hypericins for several samples of natural products were determined by spectrophotometric methods, while the identification and quantitative analysis of polyphenolic compounds by HPLC/UV/MS, and hypericin and hyperforin by LC/MS methods. The content in bioactive compounds was higher in H. perforatum compared with H. hirsutum: flavonoids (3.88 -5.19% and 1.92 -3.58%, respectively), and total hypericins (0.42 -0.65% and 0.13 -0.29% respectively). Major differences between the two species were observed: rutin and hyperoside were the main polyphenols in H. perforatum extract, while in H. hirsutum isoquercitrin and hyperoside were predominants, and rutin was found only in traces. Significantly higher amounts of hyperforin and hypericin were determined by LC/MS in H. perforatum extract. RezumatObiectivul studiului a fost analiza fitochimică a părţilor aeriene de Hypericum perforatum şi H. hirsutum recoltate din zone diferite din Transilvania (România). Pentru mai multe probe s-au determinat flavonoidele totale şi hipericinele totale prin metode spectrofotometrice, identificarea şi cuantificarea compuşilor polifenolici s-au efectuat prin HPLC/UV/MS, iar a hipericinei şi hiperforinei prin metode LC/MS. Conţinutul în compuşi bioactivi a fost mai mare în extractele de H. perforatum faţă de cele de H. hirsutum: 3,88 -5,19% şi respectiv 1,92 -3,58% flavonoide, şi 0,42 -0,65% şi respectiv 0,13 -0,29% hipericine totale. S-au observat diferenţe majore între speciile analizate: rutozida şi hiperozida au fost compuşii polifenolici majoritari din extractul de H. perforatum, iar isoquercitrozida şi hiperozida în cel de H. hirsutum, iar rutozida a fost detectată doar în urme. Concentraţiile de hipericină şi hiperforină determinate prin LC/MS au fost semnificativ mai mari în extractul de H. perforatum.

show abstract

PDR for Herbal Medicines

Cited by 13 publications

References 0 publications

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

The protective effect of Fumaria officinalis against the testicular toxicity of fluoxetine in rat

Comparative Phytochemical Profile of Hypericum Perforatum and Hypericum Hirsutum (Hypericaceae)

Contact Info

Product

Resources

About