PDMS Anatomical Realistic Models for Hemodynamic Studies Using Rapid Prototyping Technology

Queijo, Luís; Lima, Rui

doi:10.1007/978-3-642-14515-5_111

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…However, even performing these studies in animal models, neither human physiology nor human disease is fully recapitulated. In these types of experiments, the measurements are often inaccurate, and the experiments are expensive, have low reproducibility, and have associated ethical issues [3][4][5][6]. Therefore, engineered in vitro biomodels have gained widespread attention and have been developed to overcome those limitations.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

Carvalho

Rodrigues

Ribeiro³

et al. 2020

Micromachines

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Atherosclerosis is one of the most serious and common forms of cardiovascular disease and a major cause of death and disability worldwide. It is a multifactorial and complex disease that promoted several hemodynamic studies. Although in vivo studies more accurately represent the physiological conditions, in vitro experiments more reliably control several physiological variables and most adequately validate numerical flow studies. Here, a hemodynamic study in idealized stenotic and healthy coronary arteries is presented by applying both numerical and in vitro approaches through computational fluid dynamics simulations and a high-speed video microscopy technique, respectively. By means of stereolithography 3D printing technology, biomodels with three different resolutions were used to perform experimental flow studies. The results showed that the biomodel printed with a resolution of 50 μm was able to most accurately visualize flow due to its lowest roughness values (Ra = 1.8 μm). The flow experimental results showed a qualitatively good agreement with the blood flow numerical data, providing a clear observation of recirculation regions when the diameter reduction reached 60%.

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Section: Introductionmentioning

confidence: 99%

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

Carvalho

Rodrigues

Ribeiro³

et al. 2020

Micromachines

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“…Goudot et al [32] showed the ability of ultrafast ultrasound imaging to evaluate local flow velocities over an entire 2D image, which allowed the obtention of accurate measurements of wall shear stress (WSS) when compared to conventional ultrasound imaging. Although research has progressed to overcome the difficulties of in vivo measurements, these methods are still expensive, have low reproducibility, and require ethical and regulatory considerations [33,34].…”

Section: Introductionmentioning

confidence: 99%

In vitro Biomodels in Stenotic Arteries to Perform Blood Analogues Flow Visualizations and Measurements: A Review

Carvalho¹,

Maia²,

Souza³

et al. 2020

TOBEJ

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Cardiovascular diseases are one of the leading causes of death globally and the most common pathological process is atherosclerosis. Over the years, these cardiovascular complications have been extensively studied by applying in vivo, in vitro and numerical methods (in silico). In vivo studies represent more accurately the physiological conditions and provide the most realistic data. Nevertheless, these approaches are expensive, and it is complex to control several physiological variables. Hence, the continuous effort to find reliable alternative methods has been growing. In the last decades, numerical simulations have been widely used to assess the blood flow behavior in stenotic arteries and, consequently, providing insights into the cardiovascular disease condition, its progression and therapeutic optimization. However, it is necessary to ensure its accuracy and reliability by comparing the numerical simulations with clinical and experimental data. For this reason, with the progress of the in vitro flow measurement techniques and rapid prototyping, experimental investigation of hemodynamics has gained widespread attention. The present work reviews state-of-the-art in vitro macro-scale arterial stenotic biomodels for flow measurements, summarizing the different fabrication methods, blood analogues and highlighting advantages and limitations of the most used techniques.

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“…These materials are characterized by the high deformations that they exhibit before reaching the tensile strength [2]. In order to find a material with hyperelastic properties close to arterial tissues, aneurysms in vitro models made of polydimethylsiloxane (PDMS) are gaining popularity among the biomedical research community [6][7][8][9]. PDMS is a biomaterial known for its biocompatibility and low cost, which makes this material extremely popular in several biomedical applications, such as the development of biomedical microfluidic devices and organs-on-a-chip platforms [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Hyperelastic Behaviour in Aneurysm Models

2017

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PDMS Anatomical Realistic Models for Hemodynamic Studies Using Rapid Prototyping Technology

Cited by 5 publications

References 6 publications

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study

In vitro Biomodels in Stenotic Arteries to Perform Blood Analogues Flow Visualizations and Measurements: A Review

Numerical Simulation of Hyperelastic Behaviour in Aneurysm Models

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