PDIA3 knockout abrogate effects of 1,25(OH)2D3 on cellular respiration and glycolysis in squamous cell carcinoma
Joanna I. Nowak,
Anna Olszewska,
Oliwia Król
et al.
Abstract:PDIA3 is an endoplasmic reticulum disulfide isomerase which is involved in the folding and trafficking of newly synthesized proteins. PDIA3 was also described as an alternative receptor for the active form of vitamin D 1,25(OH)2D3. Here, we investigated the impact of PDIA3 in mitochondrial morphology and bioenergetics in squamous cell carcinoma line A431 treated with 1,25(OH)2D3. It was observed that PDIA3 deletion resulted in changes in morphology of mitochondria including a decrease in the percentage of mito… Show more
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