PDGF: the nuts and bolts of signalling toolbox

Abstract

PDGF is a growth factor and is extensively involved in multi-dimensional cellular dynamics. It switches on a plethora of molecules other than its classical pathway. It is engaged in various transitions of development; however, if the unleashed potentials lead astray, it brings forth tumourigenesis. Conventionally, it has been assumed that the components of this signalling pathway show fidelity and act with a high degree of autonomy. However, as illustrated by the PDGF signal transduction, reinterpretation of recent data suggests that machinery is often shared between multiple pathways, and other components crosstalk to each other through multiple mechanisms. It is important to note that metastatic cascade is an intricate process that we have only begun to understand in recent years. Many of the early steps of this PDGF cascade are not readily targetable in the clinic. In this review, we will unravel the paradoxes with reference to mitrons and cellular plasticity and discuss how disruption of signalling cascade triggers cellular proliferation phase transition and metastasis. We will also focus on the therapeutic interventions to counteract resultant molecular disorders.

MicroRNA-219-5p functions as a tumor suppressor partially by targeting platelet-derived growth factor receptor alpha in colorectal cancer

“…Overexpression of miR-219-5p reduced the activation of PI3K/Akt pathway, suggesting that the down-regulation of miR-219-5p could be contributing to the increased activity of these pathways in CRC. However, PDGFRα, which was littler detected in colon cancer cells [35], could activate other RTK pathways for expanding its effect when sensitized [17]. And our experiment didn't perform the exogenous PDGFRα rescue assay in miR-219-5p overexpressed cells to illustrate the specificity of miR-219-5p/ PDGFRα axis.…”

“…The PDGF receptor (PDGFR) signaling pathway is involved in the progression of cancer [16,17] and can be activated through the autocrine system to promote cell proliferation and survival, improve migration and invasion abilities, and stimulate angiogenesis in cancer [16][17][18]. Recent research revealed that PDGFR was upregulated in CRC and correlated with advanced tumor stage and lymph node metastasis [19].…”

Aptamer and rolling circle amplification-involved sandwich assay for platelet-derived growth factor-BB with absorbance analysis

“…PDGF-BB has a direct relationship with cell transformation and tumour growth and progression. [8][9][10] Normally, it is expressed at undetectable or low levels, but it is overexpressed in malignant tumour cells. Therefore, sensitive detection of PDGF-BB is quite important for effective diagnosis and prognosis of many diseases.…”

PDGFRB-rearranged T-lymphoblastic leukemia/lymphoma occurring with myeloid neoplasms: the missing link supporting a stem cell origin

“…8,9 Mutated PDGF signaling components have been identified in a number of neoplasms. Notably, a transgenic mouse model directing the ETV6-PDGFRB fusion protein to lymphoid cells demonstrated the development of B-and T-LBLs.…”