PDGF‐C and ‐D and their receptors PDGFR‐α and PDGFR‐β in atherosclerotic human arteries

Abstract

Our results suggest that PDGF-C may play an important role in endothelium in normal and atherosclerotic arteries and in macrophages in lesions. PDGF-D was expressed in all types of lesions with the same intensity and thus differs from the expression of PDGF-C.

Gambogic Acid Induces G0/G1 Cell Cycle Arrest and Cell Migration Inhibition Via Suppressing PDGF Receptor β Tyrosine Phosphorylation and Rac1 Activity in Rat Aortic Smooth Muscle Cells

“…Much A B evidence indicates that PDGF-BB and its receptor PDGFR--mediated signals are particularly important for vascular remodeling and neointima formation after vascular injury. Moreover, inhibition of PDGF signaling, which potentially prevents atherogenesis, has been confirmed in various models 5,31,32) . Therefore, inhibition of PDGF-induced VSMC proliferation and migration represents a key pharmacologic strategy during atherogenesis development.…”

Cytochrome P450 1B1 Contributes to the Development of Angiotensin II–Induced Aortic Aneurysm in Male Apoe−/− Mice

“…PDGF-D is a relatively novel member of PDGFs, which signal via Pdgfrb. 29,30 It stimulates VSMC migration and proliferation, monocytes/macrophage recruitment, and increased secretion of MMPs in various cell types. 46,47 Although we did not assess the involvement of VSMCs specifically in this study, we did observe enhanced macrophage and T-cell infiltration and MMP expression at the site of aortic lesion.…”

“…PDGF-D is known to signal via Pdgfrb. 30 Itga2 is a component of the Itg-a2 b 1 subunit, a major collagen receptor found in …”

Platelet-derived Growth Factor-DD Targeting Arrests Pathological Angiogenesis by Modulating Glycogen Synthase Kinase-3β Phosphorylation

“…Several mechanisms underlie the antiangiogenic effect of PDGF-DD targeting. First, PDGF-DD is expressed by macrophages (13) and is a potent chemoattractant for them (18). It is known that macrophages play an important role in pathological angiogenesis (75).…”

“…PDGF-DD protein is produced as a secreted homodimer and needs to be proteolytically processed for receptor binding (10). PDGF-DD is expressed in many different tissues (10,11) and cells, including vascular fibroblastic adventitial cells (12), artery medial smooth muscle cells (13), and endothelial cells (13). PDGF-DD expression can also be found in the neointima of arteries in chronic allograft nephropathy (14).…”