PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon

Watarai, Hiroshi; Sekine, Etsuko; Inoue, Sayo; Nakagawa, Ryusuke; Kaisho, Tsuneyasu; Taniguchi, Masaru

doi:10.1073/pnas.0710351105

Cited by 77 publications

(83 citation statements)

References 46 publications

(46 reference statements)

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“…42,57 In the immune system, plexin-A1 is specifically expressed in DCs, where it mediates the activation of T cells and the production of type I interferon. 20,58,59 The generation of antigen-specific T cells is impaired in plexin-A1 2/2 mice. 20 Sema6D, which is expressed in T cells, B cell and natural killer cells, was identified as a putative ligand for plexin-A1.…”

Section: Regulation Of Immune Cell Responses H Takamatsu Et Al 84mentioning

confidence: 99%

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Regulation of immune cell responses by semaphorins and their receptors

2010

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Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called 'immune semaphorins', are crucially involved in various phases of immune responses. These semaphorins regulate both immune cell interactions and immune cell trafficking during physiological and pathological immune responses. Here, we review the following two functional aspects of semaphorins and their receptors in immune responses: their functions in cell-cell interactions and their involvement in immune cell trafficking.

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Section: Regulation Of Immune Cell Responses H Takamatsu Et Al 84mentioning

confidence: 99%

“…Plexin-A1 forms a receptor complex with the TREM family of proteins and the adaptor molecule DAP12. 20,58 Both DAP12-deficient and plexin-A1-deficient mice not …”

Section: Regulation Of Immune Cell Responses H Takamatsu Et Al 84mentioning

confidence: 99%

Regulation of immune cell responses by semaphorins and their receptors

2010

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“…GM-CSFR␣-Ig was purified from the culture supernatants of transfected HEK293 cells using a protein A-Sepharose column as previously described 32 (GE Healthcare; supplemental Figure 1A). Anti-GM-CSFR␣ monoclonal antibody (mAb; 3A6D1) was developed by immunization of Wister rats with GM-CSFR␣-Ig.…”

Section: Generation Of Anti-gm-csfr␣ Mabmentioning

confidence: 99%

Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene

Watarai

Rybouchkin²,

Hongo

et al. 2010

Blood

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Establishment of a system with efficient generation of natural killer T (NKT) cells from embryonic stem (ES) cells would enable us to identify the cells with NKT- IntroductionNatural killer T (NKT) cells are characterized by their expression of an invariant receptor encoded by V␣14-J␣18 in mice 1 and by V␣24-J␣18 in humans. 2,3 Because the invariant receptor is used only by NKT cells and not by conventional T cells, NKT cells are a distinct lineage from conventional T cells. NKT cells produce both T helper 1 (Th1) and Th2 cytokines, mediating strong adjuvant activity through their Th1 cytokine production essential for protective responses against tumors 4-6 and pathogens 7-9 and also protecting autoimmune disease development through their Th2 cytokine production. 10,11 Despite the importance of this cell type in the immune system, the identity of NKT progenitor cells and their subsequent development remain poorly understood. In previous reports, cells with NKT-cell potential were detected in the CD4CD8 double-positive (DP) thymocyte population, 12,13 indicating that NKT cells are branched off from conventional ␣␤T-cell precursors at the DP stage in the thymus. [12][13][14] It has also been shown that the early immature CD4 NKT cells produce only interleukin-4 (IL-4), but their potential to produce interferon ␥ (IFN-␥) is acquired at a later developmental stage. 15,16 However, it is still possible that NKT cells might be derived from a precursor population distinct from that of conventional ␣␤T cells, because it has previously been shown that NKT precursor cells express on their cell surface granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR), 17 which is known to be a unique marker for myeloid cell lineages but not for lymphoid cells. In addition, because the invariant V␣14 receptor is used only by NKT cells and not by conventional T cells, NKT cells may be a distinct lineage from conventional ␣␤T cells. 18 Embryonic stem (ES) cells are a powerful model system in which to study in vitro lymphocyte differentiation, addressing the questions on the cells with NKT precursor potential and the ability of NKT cells to produce both Th1 and Th2 cytokines during their development. For example, embryoid bodies generated from ES cells contain CD34 ϩ cells that develop into lymphocytes when cocultured with OP9 stromal cells plus appropriate cytokines. 19 However, in most cases, ES cells generate B and NK cells, but not T or NKT cells on OP9 coculture. 20,21 To overcome these problems, OP9 stromal cells transduced with Notch ligand delta-like1 (OP9/Dll-1) are used for the directed differentiation of ES cells to T-cell lineages. Induction of Notch signals directs stem cells to differentiate into immature DP T cells and inhibits B-cell development, indicating that Notch signaling is required as a proximal event in T-cell commitment from progenitors. 22,23 Another approach is to use cloned ES (NKT-ES) cells established by nuclear transfer of a cell with a rearranged T-cell receptor (TCR) gene. 24,25 Interestingly...

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“…Based on these observations, we postulated that T cells express a Sema protein that interacts with Plxna1 in a simple ligandreceptor pairing. However, recent publications have revealed that similar to the TNF, CD28, and B7 families, immune cells express numerous Sema and Plex ligand-receptor pairs with multiple proteins interacting within a functional group (8)(9)(10)(11)(12). For example, during DC and T cell interactions, combinations of the following known receptor-ligand pairs are expressed: Plxna1-Sema3A, Sema3A-Plxna4, Plxna1-Sema6D, and Plxna4-Sema6D.…”

mentioning

confidence: 99%

“…Moreover, the expression patterns also suggest the potential for homotypic pairings during T cell-T cell contact or DC-DC contact. Finally, the identification of Sema and Plex expression by multiple immune cell types increases the potential for complex cell-cell interactions beyond a simple DC and T cell model of regulation (11,13). The multivariate interactions of Sema and Plex proteins are difficult to characterize, especially given that the majority of functional studies have relied on knockout mice with potential developmental disruptions in which multiple tissues, interactions, cell types, and maturation states may be affected (12).…”

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confidence: 99%

Semaphorin 6D regulates the late phase of CD4 ⁺ T cell primary immune responses

O’Connor

Eun

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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The semaphorin and plexin family of ligand and receptor proteins provides important axon guidance cues required for development. Recent studies have expanded the role of semaphorins and plexins in the regulation of cardiac, circulatory and immune system function. Within the immune system, semaphorins and plexins regulate cell-cell interactions through a complex network of receptor and ligand pairs. Immune cells at different stages of development often express multiple semaphorins and plexins, leading to multivariate interactions, involving more than one ligand and receptor within each functional group. Because of this complexity, the significance of semaphorin and plexin regulation on individual immune cell types has yet to be fully appreciated. In this work, we examined the regulation of T cells by semaphorin 6D. Both in vitro and in vivo T cell stimulation enhanced semaphorin 6D expression. However, semaphorin 6D was only expressed by a majority of T cells during the late phases of activation. Consequently, the targeted disruption of semaphorin 6D receptor-ligand interactions inhibited T cell proliferation at late but not early phases of activation. This proliferation defect was associated with reduced linker of activated T cells protein phosphorylation, which may reflect semaphorin 6D regulation of c-Abl kinase activity. Semaphorin 6D disruption also inhibited expression of CD127, which is required during the multiphase antigen-presenting cell and T cell interactions leading to selection of long-lived lymphocytes. This work reveals a role for semaphorin 6D as a regulator of the late phase of primary immune responses.immune regulation ͉ lymphocyte selection ͉ response maturation

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PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon

Cited by 77 publications

References 46 publications

Regulation of immune cell responses by semaphorins and their receptors

Regulation of immune cell responses by semaphorins and their receptors

Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene

Semaphorin 6D regulates the late phase of CD4 ⁺ T cell primary immune responses

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PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon

Cited by 77 publications

References 46 publications

Regulation of immune cell responses by semaphorins and their receptors

Regulation of immune cell responses by semaphorins and their receptors

Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene

Semaphorin 6D regulates the late phase of CD4 + T cell primary immune responses

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Semaphorin 6D regulates the late phase of CD4 ⁺ T cell primary immune responses