Pd34-06 the Effect of Nsaid Use on Disease Progression in Patients on Active Surveillance for Prostate Cancer

Nonsteroidal Anti-inflammatory Drugs and Clinical Outcomes among Men with Prostate Cancer: A Systematic Review and Meta-analysis

“…We identified 24 observational studies and two randomized controlled studies with a total pooled cohort of 89,436 men with PCa. The included studies had a total of 69,247 men from 20 retrospective cohort studies, [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]40,41] 13,855 men from two prospective cohort studies, [34,35] 1619 men from one case cohort study [36] and 4715 men from one nested case-control study, [37] and 300 men from two prospective randomized controlled studies. [38,39] Seventeen studies were carried out in the United States, [16][17][18]20,21,[26][27][28][31][32][33][34][35][38][39][40]41] three in the United Kingdom (UK), [22,29,37] two in Canada, [24,…”

“…[18] All the included studies had at least 1 year of median follow-up period with a maximum median duration of 9.25 years in a study. [32] Seven of the included studies restricted their study cohort to localized PCa [18,20,24,28,29,31,32] and one study included men with advance PCa, [27] whereas the rest of studies did not restrict their cohort based on PCa stage. Six studies included men with PCa treated with radiation therapy (RT), [16,23,24,27,31,33] five studies restricted the study cohort to men with PCa treated with radical prostatectomy (RP), [18][19][20]26,38] one study had men with active surveillance, [32] and the rest of the included men were diagnosed with PCa without restricting them to any primary PCa treatment such as RP/RT.…”

“…Details on each of the three domains for risk of bias selection, ascertainment of exposure and outcomes, and comparability for observational studies are provided in Appendix 1.1-1.3 and the risk of bias table for RCT are provided in Appendix 1.4. Out of the 24 observational studies, ten utilized single institutional data, [18][19][20][21]23,26,28,[31][32][33] seven utilized survey or prospective cohort data, [16,17,27,30,34,35,40] and six studies utilized cancer registry-linked electronic medical records or administrative claim databases. [22,24,25,29,36,37] The coding algorithms for PCa were not defined with their diagnostic accuracy in single institutional data.…”