PD11-10 PROSTATE-SPECIFIC DELETION OF Cdh1 IN MICE MIMICS PROSTATIC PERFUSION OF BENIGN PROSTATIC HYPERPLASIA (BPH) PATIENTS

Tyagi, Pradeep; Pascal, Laura E; Foley, Lesley M.; Frederick, Robin; Hitchens, T. Kevin; Kanai, Anthony; Yoshimura, Naoki; Wang, Zhou

doi:10.1097/ju.0000000000001986.10

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“…GBCA injected for DCE-MRI is also excreted unchanged in urine, and its continuous accumulation in the lumen [44][45][46] rapidly reduces the image contrast between the lumen and bladder wall (Figure 4) [32,47,48] due to pseudolayering, which leaves a rapidly closing window for bladder tumor imaging by DCE-MRI (<3 min) [34][35][36]. While the relationship between GBCA concentration and T1 relaxation rate is linear [30,31], a non-linear relationship between GBCA concentration and the signal intensity (Figure 4) [45,49,50] results in the phenomenon of pseudolayering [45,51,52] (inset of Figure 4) due to the concentration-dependent T1-and T2-shortening effect of Gadobutrol [45].…”

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confidence: 99%

Intravesical Contrast-Enhanced MRI: A Potential Tool for Bladder Cancer Surveillance and Staging

et al. 2023

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This review article gives an overview of the current state of the art of bladder cancer imaging and then discusses in depth the scientific and technical merit of a novel imaging approach, tracing its evolution from murine cancer models to cancer patients. While the poor resolution of soft tissue obtained by widely available imaging options such as abdominal sonography and radiation-based CT leaves them only suitable for measuring the gross tumor volume and bladder wall thickening, dynamic contrast-enhanced magnetic resolution imaging (DCE MRI) is demonstrably superior in resolving muscle invasion. However, major barriers still exist in its adoption. Instead of injection for DCE-MRI, intravesical contrast-enhanced MRI (ICE-MRI) instills Gadolinium chelate (Gadobutrol) together with trace amounts of superparamagnetic agents for measurement of tumor volume, depth, and aggressiveness. ICE-MRI leverages leaky tight junctions to accelerate passive paracellular diffusion of Gadobutrol (604.71 Daltons) by treading the paracellular ingress pathway of fluorescein sodium and of mitomycin (<400 Daltons) into bladder tumor. The soaring cost of diagnosis and care of bladder cancer could be mitigated by reducing the use of expensive operating room resources with a potential non-surgical imaging option for cancer surveillance, thereby reducing over-diagnosis and over-treatment and increasing organ preservation.

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