PD1 CD44 antiviral peptide as an inhibitor of the protein-protein interaction in dengue virus invasion

Recalde-Reyes, Delia Piedad; Rodríguez-Salazar, Carlos Andrés; Castaño-Osorio, Jhon Carlos; Giraldo, María Isabel

doi:10.1016/j.peptides.2022.170797

Cited by 4 publications

(1 citation statement)

References 66 publications

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“…The PD1 CD44 peptide was able to effectively inhibit DENV-1 to 4 infections by binding to domain III of the DENV E protein. This interaction presumably blocked the interaction between the DENV E protein and the CD44 receptor, thus resulting in inhibition of DENV-1 to 4 infections [ 76 ]. A heparan sulfate mimetic, PG545, potently inhibited DENV-2 with an IC 50 value of 25 nM.…”

Section: Modes Of Action Of Antiviralsmentioning

confidence: 99%

Molecular Mechanisms of Antiviral Agents against Dengue Virus

Lee

Poh

2023

Viruses

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Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics. Various antiviral agents have been developed and investigated for their anti-DENV activities. This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting host receptors and direct-acting antivirals targeting DENV structural and non-structural proteins are reviewed. In addition, the development of antivirals that target different stages during post-infection such as viral replication, viral maturation, and viral assembly are reviewed. Antiviral agents designed based on these molecular mechanisms of action could lead to the discovery and development of novel anti-DENV therapeutics for the treatment of dengue infections. Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.

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Section: Modes Of Action Of Antiviralsmentioning

confidence: 99%