Pd nanoparticles and molybdenum disulfide (MoS2) integrated sensing platform for the detection of neuromodulator

Jain, Utkarsh; Khanuja, Manika; Gupta, Shruti; Harikumar, Anjali; Chauhan, Nidhi

doi:10.1016/j.procbio.2019.03.019

Cited by 18 publications

(8 citation statements)

References 36 publications

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“…Co-immobilization of AChE and ChOx was carried out after drop-casting chitosan on Pd-MoS 2 -Au-ET (Figure D). This sensor was stable for about 90 days and exhibited a low detection limit of 1 nM, which is superior than earlier reports for the quantification of these analytes . Highly porous gold (HPG) was electroplated over a platinum electrode followed by immobilization of AChE using electrodeposition, and this electrode was used for sensing studies .…”

Section: Acetylcholine (Ach)mentioning

confidence: 96%

Section: Acetylcholine (Ach)mentioning

confidence: 99%

Section: Acetylcholine (Ach)mentioning

confidence: 99%

“…This sensor was stable for about 90 days and exhibited a low detection limit of 1 nM, which is superior than earlier reports for the quantification of these analytes. 61 Highly porous gold (HPG) was electroplated over a platinum electrode followed by immobilization of AChE using electrodeposition, and this electrode was used for sensing studies. 50 Ion selective electrodes made up of poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) were also used for electrochemical detection of ACh.…”

Section: ■ Acetylcholine (Ach)mentioning

confidence: 99%

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“Nano”: An Emerging Avenue in Electrochemical Detection of Neurotransmitters

Madhurantakam

Karnam

Brabazon

et al. 2020

ACS Chem. Neurosci.

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The growing importance of nanomaterials toward the detection of neurotransmitter molecules has been chronicled in this review. Neurotransmitters (NTs) are chemicals that serve as messengers in synaptic transmission and are key players in brain functions. Abnormal levels of NTs are associated with numerous psychotic and neurodegenerative diseases. Therefore, their sensitive and robust detection is of great significance in clinical diagnostics. For more than three decades, electrochemical sensors have made a mark toward clinical detection of NTs. The superiority of these electrochemical sensors lies in their ability to enable sensitive, simple, rapid, and selective determination of analyte molecules while remaining relatively inexpensive. Additionally, these sensors are capable of being integrated in robust, portable, and miniaturized devices to establish point-of-care diagnostic platforms. Nanomaterials have emerged as promising materials with significant implications for electrochemical sensing due to their inherent capability to achieve high surface coverage, superior sensitivity, and rapid response in addition to simple device architecture and miniaturization. Considering the enormous significance of the levels of NTs in biological systems and the advances in sensing ushered in with the integration of nanotechnology in electrochemistry, the analysis of NTs by employing nanomaterials as interface materials in various matrices has emerged as an active area of research. This review explores the advancements made in the field of electrochemical sensors for the sensitive and selective determination of NTs which have been described in the past two decades with a distinctive focus on extremely innovative attribut,es introduced by nanotechnology.

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Section: Acetylcholine (Ach)mentioning

confidence: 96%

Section: Acetylcholine (Ach)mentioning

confidence: 99%

Section: Acetylcholine (Ach)mentioning

confidence: 99%

Section: ■ Acetylcholine (Ach)mentioning

confidence: 99%

See 2 more Smart Citations

“Nano”: An Emerging Avenue in Electrochemical Detection of Neurotransmitters

Madhurantakam

Karnam

Brabazon

et al. 2020

ACS Chem. Neurosci.

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“…Modification of NPs on the electrode surface (especially onto CPs) provides higher electron transfer capability, decreases over‐potential and enhances the effective surface area . Palladium (Pd) NPs are captivating materials for many sensing applications due to their special features such as large specific surface area, high conductivity, and good electron transfer ability . Pd NPs containing various surfaces have been used for the determination of various analytes .…”

Section: Introductionmentioning

confidence: 99%

Enhanced Electrochemical Determination of Catechol and Hydroquinone Based on Pd Nanoparticles/Poly(Taurine) Modified Glassy Carbon Electrode

Koçak

2019

Electroanalysis

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Here, Pd nanoparticles and poly(taurine) film was prepared on the glassy carbon electrode surface (Pd/Poly(TAU)/GCE) by the rapid electrochemical technique. The proposed composite surface was characterized by scanning electron microscopy(SEM), X‐ray photoelectron spectroscopy(XPS) and electrochemical impedance spectroscopy(EIS). Enhanced electron transfer ability and higher electroactive surface area were achieved at Pd/Poly(TAU)/GCE as compared to the bare GCE and polymer film electrode. The new and highly stable Pd/Poly(TAU)/GCE was employed for the individual and simultaneous determination of hydroquinone and catechol which were environmentally toxic. Under the optimized conditions, HQ and CC were individually determined by using the differantial pulse voltammetry in the linear ranges of 0.008–100 μM and 0.001–100 μM with the detection limits of (LOD) 2.1 nM and 0.68 nM, respectively. In case of simultaneous determination, LODs were found as 10 nM and 0.88 nM for HQ and CC, respectively. The content of both analytes in the real sample analysis was evaluated in the river water and tap water successfully.

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