PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy

Chang, Yih‐Leong; Yang, Ching‐Yao; Lin, Mong-Wei; Wu, Chen-Tu; Yang, Pan‐Chyr

doi:10.1016/j.lungcan.2015.03.017

Cited by 79 publications

(91 citation statements)

References 37 publications

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“…More research is needed to determine the optimal assay and cutoff for determining PD-L1 positivity. Three retrospective series analyzed PD-L1 expression in a total of 258 cases of LELC of the lung (11)(12)(13). The threshold for a positive result was membranous expression in >5% tumor cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature

Kim

Rajan

DeBrito

et al. 2016

Transl. Lung Cancer Res.

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Section: Discussionmentioning

confidence: 99%

“…For example, in a study from Taiwan, EGFR mutations were detected only in 12.1% of patients and there were no ALK or ROS1 genetic aberrations (11). Another study of 42 patients with LELC of the lung showed that there was only one patient (2.4%) with EGFR activating mutation (L858R) and none of the patients had ALK rearrangement (40).…”

Section: Discussionmentioning

confidence: 99%

Metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature

Kim

Rajan

DeBrito

et al. 2016

Transl. Lung Cancer Res.

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“…PD-L1 expression was described in other EBV-associated malignancies [11][12][13] and several studies have reported positive PD-L1 expression in 25-89% of NPCs [14][15][16][17]. In contrast to EBV-associated gastric adenocarcinomas in which expression of PD-L1 protein may result from PD-L1 gene amplification [18], NPCs do not have PD-L1 gene copy number change [19].…”

Section: Introductionmentioning

confidence: 99%

Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein–Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines

Chang

Chiosea

Altman

et al. 2016

Head and Neck Pathol

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Most nasopharyngeal carcinomas (NPCs) in a high-incidence population are driven by Epstein-Barr virus (EBV) infection. EBV-associated malignancies have increased expression of the programmed death-ligand 1 (PD-L1). Immunotherapy agents targeting the PD-1/PD-L1 pathway have achieved durable treatment effects in patients with various cancer types including EBV-associated malignancies. In this study, we sought to investigate PD-L1 expression in a cohort of patients with NPCs from the Philippines. Fifty-six NPCs were studied for PD-L1, p16, and DNA mismatch repair (MMR) deficiency by immunohistochemistry. One case with MMR deficiency was also assessed for microsatellite instability (MSI) by polymerase chain reaction. EBV and human papillomavirus (HPV) status were tested by in situ hybridization. All NPCs were p16 negative. Three of the 56 NPCs (5%) were EBV negative (EBV-) and HPV negative, while one NPC (1/56, 2%) was EBV positive and showed MSI (EBV?/MSI). Positive PD-L1 expression (PD-L1?), defined as membranous staining in C1% tumor cells, was seen in 64% (36/56) of NPCs. All three EBV-NPCs were PD-L1? as was the EBV?/MSI NPC. PD-L1? was seen significantly more often in NPCs from non-smokers than those from smokers (23/28, 82% vs 9/18, 50%; P = 0.047). PD-L1? was not associated with pT, pN, distant metastasis, or clinical stage (P [ 0.05). PD-L1? was not associated with overall survival (P = 0.473). In summary, our results show frequent PD-L1 expression in NPCs regardless of EBV status and a preferential PD-L1 expression in non-smokers. MSI and HPV positivity are exceedingly rare in NPCs.

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“…PD-L1 expression can be used as a prognostic indicator predictive of better survival in patients with surgically resected stage I lung adenocarcinomas and squamous cell carcinoma (35,36). High PD-L1 expression and infrequent driver mutation was found in LELCs compared with conventional NSCLCs (37). The high expression of PD-L1 in inflammation associated LELC may provide a rationale for immunotherapy in this subtype of lung cancer.…”

Section: Nsclcmentioning

confidence: 97%

“…We investigated the prognostic roles of PD-L1 and the immune microenvironment in different types of early stage NSCLC, including adenocarcinoma (35), squamous cell carcinoma (36), lung lymphoepithelioma-like carcinoma (LELC) (37) and pleomorphic carcinoma (38). PD-L1 expression can be used as a prognostic indicator predictive of better survival in patients with surgically resected stage I lung adenocarcinomas and squamous cell carcinoma (35,36).…”

Section: Nsclcmentioning

confidence: 99%

Translational research in thoracic surgery—the National Taiwan University Hospital experience

2016

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Thoracic surgeons should be more aware of the latest information about histopathological, genetic and epigenetic alterations that may influence treatment policy and patient outcome in the biomolecular era. Translational research studies often produce a promising diagnostic tool or new treatment that can be used clinically. The results of these translational studies may even change the practical guidelines and current staging system in thoracic malignancies. The following article summarizes the experiences of translational research in esophageal cancer and non-small cell lung cancer (NSCLC) at National Taiwan University Hospital in Taiwan.

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PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy

Cited by 79 publications

References 37 publications

Metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature

Metastatic lymphoepithelioma-like carcinoma of the lung treated with nivolumab: a case report and focused review of literature

Programmed Death-Ligand 1 Expression, Microsatellite Instability, Epstein–Barr Virus, and Human Papillomavirus in Nasopharyngeal Carcinomas of Patients from the Philippines

Translational research in thoracic surgery—the National Taiwan University Hospital experience

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