PD-L1 as a Novel Mediator of Lung Fibroblast to Myofibroblast Transition

Guo, Xia; Qian, Guoqing

doi:10.33696/immunology.4.142

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…Besides an overexpression of PD-L1, an upregulated expression of PD-1 in CD4 + T cells in blood samples and an increased PD-1 expression in idiopathic lung fibrosis (IPF) human lung biopsies were described [ 17 , 18 ]. It is hypothesized that PD-L1/PD-1 interaction mediates fibroblasts to myofibroblast transition and potentially the development of pulmonary fibrosis [ 20 ]. Therefore, trials evaluating the potential therapeutic effect of PD-1/PD-L1 blockades on IPF are of great interest.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of PD-1 T lymphocytes in bronchoalveolar lavage in lung cancer compared to benign lung diseases

et al. 2023

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The expression of the programmed cell death protein 1 (PD-1) has been shown to be markedly increased in tumor-infiltrating lymphocytes. However, the proportion of PD-1 + T cells in the bronchoalveolar lavage (BAL) of lung cancer patients has not been sufficiently evaluated so far. In this prospective study, the proportion of PD-1 + CD4 + as well as PD-1 + CD8 + T cells in BAL samples, isolated from patients with lung cancer, asthma or interstitial lung disease (ILD), were determined via flow cytometry and compared for differences. Bronchoalveolar lavage was performed in 34 patients (14 patients with lung cancer, 10 patients with asthma, 10 patients with ILD). The highest median proportion of PD-1 + CD4 + or PD-1 + CD8 + T cells were found in patients with ILD (83.1% [IQR 72.1; 87.5] and 73.8% [IQR 60.3; 86.3]) followed by patients with lung cancer (66.4% [IQR 59; 69] and 77.1% [IQR 35.8; 82.3]) and patients with asthma (61.3% [IQR 57.4; 70.5] and 57.3% [IQR 46; 65]). Thereby, the difference in the proportion of PD-1 + CD3 + CD4 + BAL cells between ILD patients and asthmatics was significantly different (p = 0.04). The proportion of PD-1 + CD4 + and PD-1 + CD8 + T cells in the BAL of patients with lung cancer did not differ significantly to patients with benign lung diseases. The highest proportion was observed in ILD patients suggesting further research to evaluate the role of the PD-1/PD-L1 pathway in ILD patients.

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Section: Discussionmentioning

confidence: 99%