PD-L1 antibody enhanced β-glucan antitumor effects via blockade of the immune checkpoints in a melanoma model

Hu, Xin; Shui, Yifang; Honda, Hiroshi; Kusano, Kisato; Guo, Wenzhi; Fujino, Masayuki; Li, Xiaokang

doi:10.1007/s00262-022-03276-4

Cited by 6 publications

(4 citation statements)

References 69 publications

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“…The frequency of tumor‐infiltrating B lymphocytes, which can enhance antitumor immunity by presenting antigens and secreting inflammatory cytokines and antibodies, [ 41 , 42 ] was also markedly increased after ES@CuO+PD‐1 therapy (Figure S21 , Supporting Information). Furthermore, the levels of interleukin 6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and interferon‐γ (IFN‐γ), which further robustly activate immune responses, [ 43 , 44 ] substantially increased in the mice treated with ES@CuO+PD‐1 (Figure 6H–J ). Together, these results confirmed that ES@CuO+PD‐1 therapy facilitated antitumor efficacy by effectively reprogramming the immunosuppressive TME.…”

Section: Resultsmentioning

confidence: 99%

Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy

Lu,

Chen,

Lin

et al. 2024

Advanced Science

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The induction of cuproptosis, a recently identified form of copper‐dependent immunogenic cell death, is a promising approach for antitumor therapy. However, sufficient accumulation of intracellular copper ions (Cu2+) in tumor cells is essential for inducing cuproptosis. Herein, an intelligent cuproptosis‐inducing nanosystem is constructed by encapsulating copper oxide (CuO) nanoparticles with the copper ionophore elesclomol (ES). After uptake by tumor cells, ES@CuO is degraded to release Cu2+ and ES to synergistically trigger cuproptosis, thereby significantly inhibiting the tumor growth of murine B16 melanoma cells. Moreover, ES@CuO further promoted cuproptosis‐mediated immune responses and reprogrammed the immunosuppressive tumor microenvironment by increasing the number of tumor‐infiltrating lymphocytes and secreted inflammatory cytokines. Additionally, combining ES@CuO with programmed cell death‐1 (PD‐1) immunotherapy substantially increased the antitumor efficacy in murine melanoma. Overall, the findings of this study can lead to the use of a novel strategy for cuproptosis‐mediated antitumor therapy, which may enhance the efficacy of immune checkpoint inhibitor therapy.

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Section: Resultsmentioning

confidence: 99%

Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy

Lu,

Chen,

Lin

et al. 2024

Advanced Science

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“…Yields of 2.5 g l −1 are obtained with A. pullulans IMS822 KCTC 11179BP wild type (Kang et al 2010 ), while 9.2 g l −1 is obtained with the UV mutant strain A. pullulans M-2 (Moriya et al 2013 ). In general, β-glucans exhibit properties such as anticancer and anti-inflammatory activity, dermal wound healing, and enhancement of intestinal immune function in mice (Hu et al 2023 ; Kim et al 2023 ; No et al 2021 ; Tanioka et al 2013 ; Yun et al 2015 ). Of interest, Byun et al ( 2008 ) developed a gamma irradiation-based treatment for Aureobasidium β-glucan that reduces its high viscosity and poor water solubility by reducing its molecular weight.…”

Section: Bioproducts From Aureobasidiummentioning

confidence: 99%

Use of Aureobasidium in a sustainable economy

Rensink,

van Nieuwenhuijzen,

Sailer

et al. 2024

Appl Microbiol Biotechnol

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Aureobasidium is omnipresent and can be isolated from air, water bodies, soil, wood, and other plant materials, as well as inorganic materials such as rocks and marble. A total of 32 species of this fungal genus have been identified at the level of DNA, of which Aureobasidium pullulans is best known. Aureobasidium is of interest for a sustainable economy because it can be used to produce a wide variety of compounds, including enzymes, polysaccharides, and biosurfactants. Moreover, it can be used to promote plant growth and protect wood and crops. To this end, Aureobasidium cells adhere to wood or plants by producing extracellular polysaccharides, thereby forming a biofilm. This biofilm provides a sustainable alternative to petrol-based coatings and toxic chemicals. This and the fact that Aureobasidium biofilms have the potential of self-repair make them a potential engineered living material avant la lettre. Key points •Aureobasidium produces products of interest to the industry •Aureobasidium can stimulate plant growth and protect crops •Biofinish of A. pullulans is a sustainable alternative to petrol-based coatings •Aureobasidium biofilms have the potential to function as engineered living materials

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“…Based on this, β-glucan may be a good complement to PD-1 blockade therapy, and the combined therapy may overcome the deficits of the individual treatments alone. 116…”

Section: Targeting Immune Cellsmentioning

confidence: 99%

“…However, at the same time, β‐glucan enhances the expression of PD‐1 and PD‐L1 on TAMs, which in turn play immunosuppressive roles in the immune response. Based on this, β‐glucan may be a good complement to PD‐1 blockade therapy, and the combined therapy may overcome the deficits of the individual treatments alone 116 …”

Section: Combination Therapiesmentioning

confidence: 99%

Programmed cell death‐1 blockade therapy in melanoma: Resistance mechanisms and combination strategies

Zou

Yaguchi

2023

Experimental Dermatology

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Melanoma is a highly aggressive tumor derived from melanocytes. In recent years, the incidence and mortality of melanoma have gradually increased, seriously threatening human health. Classic treatments like surgery, chemotherapy, and radiotherapy show very limited efficacy. Due to the high immunogenicity of melanoma cells, immune checkpoint inhibitors have received considerable attention as melanoma treatments.One such therapy is blockade of programmed cell death-1 (PD-1), which is one of the most important negative immune regulators and is mainly expressed on activated T cells. Disruption of the interactions between PD-1 and its ligands, programmed death-ligand 1 (PD-L1) or programmed death-ligand 2 (PD-L2) rejuvenates exhausted T cells and enhances antitumor immunity. Although PD-1 blockade therapy is widely used in melanoma, a substantial proportion of patients still show no response or short durations of remission. Recent researches have focused on revealing the underlying mechanisms for resistance to this treatment and improving its efficacy through combination therapy. Here, we will introduce the resistance mechanisms associated with PD-1 blockade therapy in melanoma and review the combination therapies available.

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PD-L1 antibody enhanced β-glucan antitumor effects via blockade of the immune checkpoints in a melanoma model

Cited by 6 publications

References 69 publications

Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy

Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy

Use of Aureobasidium in a sustainable economy

Programmed cell death‐1 blockade therapy in melanoma: Resistance mechanisms and combination strategies

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