Pd-Catalyzed Picolinamide-Directed C(sp2)–H Sulfonylation of Amino Acids/Peptides with Sodium Sulfinates
Raghunath Bag,
Nagendra K. Sharma
Abstract:This
report describes a Pd-catalyzed picolinamide-directed
site-selective
C(sp2)–H sulfonylation of amino acids and peptides
with sodium sulfinates in moderate to good yields. Sulfonylation of
levodopa and dopamine drug molecules and late-stage directed peptide
sulfonylation are studied for the first time. Broad substrate scope
having various functionalities, late-stage drug modifications, and
various post synthetic utilities such as chalcogenation, bromination,
olefination, and arylation are potential advant… Show more
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