Abstract:With the aid of an innate amide group,
an intramolecular
Pd-catalyzed
enantioselective hydroamidocarbonylation reaction of α-substituted
acrylamides was developed, and a series of chiral 2-substituted succinimides
were obtained in moderate to high yields and enantioselectivities.
The generality of this approach was demonstrated by the carbonylation
of both aryl- and alkyl-substituted acrylamides containing numerous
functional groups.
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