Pd‐Catalyzed Decarboxylative Coupling Between Allyl Carbonates and Vinyl Benzoxazinanones

Abstract

In the presence of Pd(OAc)2/biphenyl‐based phosphoramidite ligand(±)‐L4,the decarboxylative coupling of allyl carbonates with vinyl benzoxazinanonesoccurred readily, and deliveredthe desired productsin the acceptable chemical yields. The chemical structure of the obtained compounds was clearly identified by a single crystal X‐ray analysis.

Pd-catalyzed decarboxylative 1,4-addition reactions of benzofuran-based azadienes with allyl phenyl carbonates

“…As for these in situ generated reactive species, on the one hand, they can couple with themselves and 5 on the other hand, they are capable of cross-coupling. 6 On the basis of previous works on the synthetic methodologies of both benzofuran-based azadienes and allyl phenyl carbonates, we devised and explored novel decarboxylative 1,4-addition reactions between benzofuran-based azadienes 1 and allyl phenyl carbonates 2 (Scheme 1-3). To our delight, we found that the newly designed decarboxylative 1,4-addition reactions proceeded efficiently and delivered structurally new and highly functionalized benzofuran skeletons with potential bioactivities 7 in acceptable chemical yields.…”