Pd‐Catalyzed Carbonylative Synthesis of 4H‐Benzo[d][1,3]Oxazin‐4‐Ones Using Benzene‐1,3,5‐Triyl Triformate as the CO Source

Abstract

A facile synthesis of 4H-benzo [d][1,3]oxazin-4-one derivatives by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo [d][1,3]oxazin-4-ones incorporated to natural products and drugs can be constructed by this method.