Pd‐Catalyzed CH Olefination Reactions

Abstract

Alkenes are valuable synthetic intermediates present in natural products, bioactive compounds, and materials. Palladium‐catalyzed CH olefination reactions have become an attractive alternative to the commonly used Pd‐catalyzed Mizoroki–Heck cross‐coupling since no prefunctionalization of the starting materials is required. Major efforts have been devoted to developing selective, efficient, and general palladium‐catalyzed CH olefination reactions employing directing groups and ligands. Nowadays, the toolbox of palladium‐catalyzed CH olefination reactions is enormous, permitting the olefination of a wide range of substrates at different positions. In this article, we will offer an overview of the most important palladium‐catalyzed CH olefination reactions of arenes and alkanes.