Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents

Abstract

Background: We report the design, synthesis and evaluation of a series of 4-biaryl substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents. Methods: The one-pot synthesis of this class of compounds was carried out under ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a key step. Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested against cancer cell lines but no or little effects on non-cancerous cell lines.

2‐Amino‐3‐cyano‐4H‐chromene‐4‐ylphosphonates as potential antiviral agents: Synthesis, in ovo and in silico approach

“…Due to broad spectrum of promising optimistic and industrial applications of alkyl phosphonate derivatives and 2-amino-4H-chromene [1][2][3][4][5] they have generated interest in developing latest methodologies for the synthesis of 2-amino-3-cyano-4H-chromene-4-ylphosphonates by coupling alkyl phosphonates with 2-aminochromene rings. (2-Amino-3-cyano-4H-chromene-4-yl) phosphonic acids diethyl esters have been outlined to have high in vitro antimicrobial and antioxidant activity.…”