Pd/C catalysts based on synthetic carbons with bi- and tri-modal pore-size distribution: applications in flow chemistry

Fan, Xiaolei; Sans, Víctor; Sharma, Sumeet K.; Pluciński, P.; Zaikovskii, Vladimir; Wilson, Karen; Tennison, S.R.; Kozynchenko, Alexander I.; Lapkin, Alexei

doi:10.1039/c5cy01401h

Cited by 12 publications

(10 citation statements)

References 40 publications

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“…5 nm (ref. [32][33][34]), with glass wool placed at each end of the chamber to hold the catalyst bed in place. The liquid and gas streams were preheated to the reaction temperature in an upfront static mixer (length = 6 cm).…”

Section: Catalytic Performance Evaluationmentioning

confidence: 99%

Continuous-flow liquid-phase dehydrogenation of 1,4-cyclohexanedione in a structured multichannel reactor

et al. 2019

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Section: Catalytic Performance Evaluationmentioning

confidence: 99%

Continuous-flow liquid-phase dehydrogenation of 1,4-cyclohexanedione in a structured multichannel reactor

et al. 2019

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“…The catalyst was based on PdNP onto tri-modal (micro, meso), hierarchical porous synthetic carbon [152]. No catalyst deactivation was detected over 5 hours continuous runs (333 K, 1 bar H 2 ).…”

Section: Reviewmentioning

confidence: 99%

Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes

Moreno‐Marrodán

Liguori

Barbaro

2017

Beilstein J. Org. Chem.

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The catalytic partial hydrogenation of substituted alkynes to alkenes is a process of high importance in the manufacture of several market chemicals. The present paper shortly reviews the heterogeneous catalytic systems engineered for this reaction under continuous flow and in the liquid phase. The main contributions appeared in the literature from 1997 up to August 2016 are discussed in terms of reactor design. A comparison with batch and industrial processes is provided whenever possible. 734

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“…Specialist catalyst development has often been targeted towards chemoselectivity. Fan et al have shown that the Pd/triC catalyst was selectively reduced alkyne groups over nitro, bromo, and aldehyde groups [50]. While Rathi's palladium nanoparticles supported on maghemite were effective in reducing nitroarenes, azides, and alkenes in good to excellent yields [52].…”

Section: New Advances In Hydrogenation Processes -Fundamentals and Apmentioning

confidence: 99%

Recent Developments in the Use of Flow Hydrogenation in the Field of Medicinal Chemistry

Russell¹,

Baker²,

Cossar³

et al. 2017

New Advances in Hydrogenation Processes - Fundamentals and Applications

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This chapter focuses on recent applications of flow hydrogenation in medicinal chemistry. Flow reactors can enhance laboratory safety, reducing the risks associated with pyrophoric catalysts, due to their containment in catalyst cartridges or omnifit columns. Flow hydrogenation reduces the risks arising from hydrogen gas, with either hydrogen generated in situ from water, or precise management of the gas flow rate through tube-in-tube reactors. There is an increasing body of evidence that flow hydrogenation enhances reduction outcomes across nitro, imine, nitrile, amide, azide, and azo reductions, together with de-aromatisation and hydrodehalogenation. In addition, olefin, alkyne, carbonyl, and benzyl reductions have been widely examined. Further, protocols involving multistage flow reactions involving hydrogenation are highlighted.

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Pd/C catalysts based on synthetic carbons with bi- and tri-modal pore-size distribution: applications in flow chemistry

Abstract: Synthetic carbons with hierarchical mesopores are promising for developing new catalysts for intensified continuous-flow catalysis in structured reactors.

Cited by 12 publications

References 40 publications

Continuous-flow liquid-phase dehydrogenation of 1,4-cyclohexanedione in a structured multichannel reactor

Continuous-flow liquid-phase dehydrogenation of 1,4-cyclohexanedione in a structured multichannel reactor

Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes

Recent Developments in the Use of Flow Hydrogenation in the Field of Medicinal Chemistry

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