PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cells in lung cancer brain metastasis.
Jens Blobner,
Laura Dengler,
Constantin Eberle
et al.
Abstract:Background
Lung cancer brain metastasis have a devastating prognosis, necessitating innovative treatment strategies. While chimeric antigen receptor (CAR) T-cells show promise in hematologic malignancies, their efficacy in solid tumors, including brain metastasis, is limited by the immunosuppressive tumor environment. The PD-L1/PD-1 pathway inhibits CAR T-cell activity in the tumor microenvironment, presenting a potential target to enhance therapeutic efficacy. This study aims to evaluate the impact of anti-P… Show more
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