Pcv146 - Systematic Literature Review of Utility Decrements Associated With the Non-Fatal Major Adverse Cardiovascular Events (Mace)

Abstract

revascularisation: 9; angina: 3) and North America (N¼6; revascularisation: 3; angina: 3). In general, utility values as per type of revascularisation (either percutaneous coronary intervention [PCI] or coronary artery bypass graft [CABG]) did not show significant differences, particularly within same studies. However, the mean values widely varied across the included studies (overall [N¼17]: 0.33-0.90; PCI [N¼10]: 0.33-0.86; CABG [N¼9]: 0.69-0.90). Majority of the studies reported improvement in utility values over time (6/8 studies). Utility values for angina, irrespective of geographical location, ranged from 0.51 to 0.81 (EQ-5D [N¼6]: 0.51-0.81; SF-6D [N¼2]: 0.62-0.78; other scales [N¼2]: 0.66-0.74). Severity of angina was associated with lower utility values. CONCLUSIONS: Overall, angina and revascularisation have a negative impact on the reported health utilities. Careful interpretation of published values is advised, given the heterogeneity of methodologies, patient populations and timing of utilities assessment reported in the available literature. Nevertheless, our results can be a valuable resource for future cost-utility analyses.