Abstract:Objectives: Real-world evidence (RWE) is increasingly considered alongside trial data to estimate relative effectiveness of treatments. However, using RWE reliably can be challenging. We examined the feasibility of using RWE to assess relative clinical effects of left atrial appendage closure (LAAC) with the WATCHMAN device and oral anticoagulants (OACs) for stroke risk reduction in nonvalvular atrial fibrillation to inform decisions on conducting a cost effectiveness analysis. Methods: A systematic literature… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.