PCR analysis of HBV infected sera: relationship between expression of pre-S antigens and viral replication

Garbuglia, A. R.; Budkowska, Agata; Taliani, Gloria; Delfini, C.; Carloni, Guido

doi:10.1007/978-3-7091-5633-9_23

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2007

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“…Our results indicate that HBpreSAg correlated well with HBV DNA copies in serum. These results are consistent with the results of Petit's[ 17 , 21 ] and Garbuglia's[ 22 ]. One difference is that Petit's data showed that PCR was an adequately sensitive method that could detect HBV DNA in roughly half of the HBpreSAg negative sera, while this ratio is 21% in our study.…”

Section: Discussionsupporting

confidence: 93%

Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients

Lian

Zhou

Wei

et al. 2007

Virol J

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Background: Hepatitis B virus (HBV) infection is a serious health problem worldwide. Treatment recommendation and response are mainly indicated by viral load, e antigen (HBeAg) seroconversion, and ALT levels. The S antigen (HBsAg) seroconversion is much less frequent. Since HBeAg can be negative in the presence of high viral replication, preS antigen (HBpreSAg) might be a useful indicator in management of chronic HBV infection.

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Section: Discussionsupporting

confidence: 93%