Pcn380 - The Prognostic Significance of Health-Related Quality of Life From Cancer Randomized Controlled Trials: A Systematic Evaluation of the Statistical Methods
Abstract:OBJECTIVES:PROs from open label trials are traditionally regarded as being more biased than PROs from double blinded studies, as the patient's knowledge of their treatment might influence their perception of their symptoms, functioning and HRQoL. We explored this hypothesis by comparing PROs from the QLQ-C30 which was used in patients treated with dabrafenib plus trametinib (D+T) for BRAF+ metastatic melanoma with the same data collection schedule in two separate studies e COMBI-D (double blinded vs dabrafenib… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.