Pcn372 Methodologies for Adjustment of the Trial Overall Survival for Treatment Switching: A Review of Nice Submissions

Abstract

Markov state-transition cohort model was developed to assess benefits and harms of five screening strategies. None of the primary studies reported adverse events or investigated consequences out of false positive or false negative test results from the viewpoint of patient safety. Full results of this HTA are published on the EUnetHTA website. Conclusions: The two DNA stool tests represent products in a series of research developments that consistently try to find better markers / analytical algorithms for the detection of CRC / precancerous lesions with a non-invasive screening test. European screening programs at the moment do not include DNA stool testing, nor is it reimbursed. Because of disease progression and prognosis the main target for these tests is to yield a positive test in persons with advanced adenomas or CRC. It may be discussed if the tests also should -preferably -yield a positive result (and colonoscopy reference) in case of non-advanced adenomas. Also test failure rates are a relevant issue.