Pcn286 Comparing Eq-5d-3l and Eq-5d-5l Psychometric Properties of Common Cancers in China: A Cross-Sectional Study

Abstract

Research assessing health-related quality of life (HRQoL) (or health state utility) which can be applied for economic evaluation in patients with Barretts esophagus (BE)and esophageal cancer is limited. This study derived health state utilities for patients with various 'stages' of BE and Cancer. Methods: A crosssectional survey was conducted with potential participants sought from South Australia, including patients with non-dysplastic BE (NDBE), low-grade dysplasia (LGD), high-grade dysplasia (HGD), or esophageal adenocarcinoma. HRQoL was assessed using two generic instruments, the EQ-5D-5L and the SF-36, and a cancerspecific instrument -the EORTC QLQ-C30. Health state utilities were derived by applying the general population preference-based scoring algorithms pertaining to all three instruments. Outcomes were compared for health states and following different treatments. Results: Ninety-seven respondents (80% male, mean age: 68 years) returned questionnaires. The mean (standard deviation) health state utilities for the total sample were 0.79 (0.24) for the EQ-5D-5L, 0.57 (0.29) for the SF-6D (derived from SF-36) and 0.73 (0.20) for the QLU-C10D (derived from EORTC QLQ-C30). No statistically significant differences were observed when different stages of BE or type of intervention received (surveillance, endoscopic treatment, surgery). However, patients who had undergone surgery for cancer reported better psychological wellbeing than those under surveillance or following endoscopic treatments. Conclusions: HRQoL for patients under surveillance for BE and following treatment of cancer was similar. Oesophagectomy was associated with better post-treatment psychological functioning, compared to endoscopic interventions, which can be attributed to a reduction in the perceived risk of cancer.