PCN221 Treatment Patterns Including Adherence/Persistence with Cyclin-Dependent Kinase 4&6 Inhibitors (CDK4&6I) Among US Commercially Insured Women with Metastatic Breast Cancer (MBC)

Treatment Experiences with CDK4&6 Inhibitors Among Women with Metastatic Breast Cancer: A Qualitative Study

“…The lack of adherence/persistence issues reported by study participants contrasts with a recent retrospective claims study of a larger population of CDK4&6i users identified from pharmacy claims data in the HIRD where only 58% of patients were classified as adherent (using proportion of days covered (PDC) ≥0.80) and 23% of patients discontinued within a 6 month period (with a permissible gap of up to 60 days). 29 However, this claims-based analysis could not account for oncologist-ordered delays in treatment or altered dosing schedules due to low white blood cells, which about half of the current participants reported. Also, while some oral oncolytics are used as adjuvant therapy for breast cancer, this study focused on the use of oral agents for advanced metastatic disease where the purpose and evaluation of the effect of the therapy may be different.…”