“…Despite the importance of mccRCC, studies evaluating its economic burden are sparse [18][19][20][21][22][23][24][25][26][27]. Most of them were conducted before 2011 and before targeted therapies appeared on the market [18][19][20][21][22]. However, targeted therapies for mccRCC have brought both new hope and new challenges, considerably expanding the number of treatment options for this indication.…”