PCL/sulfonated keratin mats for vascular tissue engineering scaffold with potential of catalytic nitric oxide generation

Dou, Jun; Wang, Yanfang; Jin, Xin; Li, Pengfei; Wang, Lijuan; Yuan, Jiang; Shen, Jian

doi:10.1016/j.msec.2019.110246

Cited by 33 publications

(19 citation statements)

References 45 publications

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“…Taking into account the quantified CLA density, this effect also corresponds to the CLA amount of the samples. The number of adhered platelets on C2-E8 was also comparable or lower regarding other studies on hemocompatibility of fibrous PCL structures [10,12]. Therefore, 3.5.…”

Section: Blood-materials Interactionsupporting

confidence: 81%

“…For instance, the incorporation of heparinimmobilized chitosan or coating of heparin-doped polypyrrole on the PCL fibers effectively improved its hemocompatibility [10,11]. Dou et al proposed the coelectrospun of sulfonated keratin with PCL to create nanofibrous mats for vascular tissue engineering [12]. Other studies probing the effect of nanomaterials embedded in PCL, such as multiwalled carbon nanotubes [13] or europium hydroxide nanorods [14], have also yielded promising results.…”

Section: Introductionmentioning

confidence: 99%

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Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane

Tran

Huynh

Phan

et al. 2020

International Journal of Polymer Science

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Polycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CLA) to prevent induced blood coagulation. The density of grafted CLA and its effects on the morphology and wettability of the membranes were examined. The study also investigated how the membrane interacted with human whole blood and platelets to determine its antithrombotic properties. As the results suggested, the grafting caused a negligible effect on the physical properties of the membrane but greatly improved its compatibility with blood, showing that the approach can be investigated further for blood-contacting applications.

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Section: Blood-materials Interactionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane

Tran

Huynh

Phan

et al. 2020

International Journal of Polymer Science

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“…PCL/sulfonated keratin co-electrospun fibrous membranes were prepared and studied as wound dressing candidates. The mats revealed optimal cell and blood compatibility [122] .…”

Section: Biomaterials For Wound Managementmentioning

confidence: 97%

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Okur

Karantas

Şenyiğit

et al. 2020

Asian Journal of Pharmaceutical Sciences

186

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Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process. Wounds can mainly be categorized as acute or chronic. It is well referred that the acute wound displays normal wound physiology while healing, in most cases, is seemed to progress through the normal phases of wound healing. On the other hand, a chronic wound is physiologically impaired. The main problem in wound management is that the majority of wounds are colonized with microbes, whereas this does not mean that all wounds will be infected. In this review, we address the problems that clinicians face to manage while treat acute and chronic wounds. Moreover, we demonstrate the pathophysiology, etiology, prognosis and microbiology of wounds. We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment. In addition, authors review researches which included the use of gels and dermal films as wound healing agents. It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards. However, are the current strategies as desirable as medical society wish?

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“…The PLA/CBS 2.5 wt.% composite exhibited an incremental aggregation tendency from PLA to CBS of 6.6%. These results can be attributed to the hydrophilicity and non-electrostatic repulsion induced by CBS, leading to platelet adhesion [86]. However, platelet activity after 1 h of exposure and before adherent platelets lysis (Figure 5d) demonstrated detachment over time, indicating that the reversible aggregation is likely to occur, therefore limiting platelet activation [87].…”

Section: Biocompatibilitymentioning

confidence: 97%

Bioactive Poly(lactic acid)–Cocoa Bean Shell Composites for Biomaterial Formulation: Preparation and Preliminary In Vitro Characterization

et al. 2021

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The unique lignocellulosic and solvent-extractive chemical constituents of most natural fibers are rich in natural polymers and bioactive molecules that can be exploited for biomaterial formulation. However, although natural fibers’ main constituents have been already incorporated as material reinforcement and improve surface bioactivity of polymeric materials, the use of the whole natural fibers as bioactive fillers remains largely unexplored. Thus, we put forward the formulation of natural fiber filling and functionalization of biomaterials by studying the chemical composition of cocoa bean shells (CBS) and proposing the fabrication and characterization of polylactic acid (PLA) and CBS-based composite by solvent-casting. As was expected from previous studies of agro-industrial wastes, the main components of CBS were to cellulose (42.23 wt.%), lignin (22.68 wt.%), hemicellulose (14.73 wt.%), and solvent extractives (14.42 wt.%). Structural analysis (FTIR) confirms the absence of covalent bonding between materials. Thermal degradation profiles (DSC and TGA) showed similar mass losses and thermal-reaction profiles for lignocellulosic-fibers-based composites. The mechanical behavior of the PLA/CBS composite shows a stiffer material behavior than the pristine material. The cell viability of Vero cells in the presence of the composites was above 94%, and the hemolytic tendency was below 5%, while platelet aggregation increased up to 40%. Antioxidant activity was confirmed with comparable 2,2-diphe-277 nyl-1-picryl-hydrazyl-hydrate (DPPH) free-radical scavenging than Vitamin C even for PLA/CBS composite. Therefore, the present study elucidates the significant promise of CBS for bioactive functionalization in biomaterial-engineering, as the tested composite exhibited high biocompatibility and strong antioxidant activity and might induce angiogenic factors’ release. Moreover, we present an eco-friendly alternative to taking advantage of chocolate-industry by-products.

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PCL/sulfonated keratin mats for vascular tissue engineering scaffold with potential of catalytic nitric oxide generation

Cited by 33 publications

References 45 publications

Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane

Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane

Recent trends on wound management: New therapeutic choices based on polymeric carriers

Bioactive Poly(lactic acid)–Cocoa Bean Shell Composites for Biomaterial Formulation: Preparation and Preliminary In Vitro Characterization

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