Pcl/Peg Electrospun Fibers as Drug Carriers for the Controlled Delivery of Dipyridamole

Repanas, Alexandros; Wf, Wolkers; O, Gryshkov; Müller, Martín; Glasmacher, Birgit

doi:10.21767/2469-6692.10003

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…As expected, the drug-free PCL mats used in this study have proven to be biocompatible with the HeLa and Ca Ski cells used (Figure 10a). It was shown previously that PCL/PEG nanofibers could control dipyridamole drugs [82]. Diclofenac sodium salt was used as the model drug in this study, as it was shown to have anti-inflammatory properties in addition to anticancer activity [37].…”

Section: Discussionmentioning

confidence: 94%

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

et al. 2021

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Diclofenac sodium salt (DSS)-loaded electrospun nanofiber mats on the base of poly(ε-caprolactone) (PCL) were investigated as biocompatible nanofibrous mats for medical applications with the ability to inhibit bacterial infections. The paper presents the characteristics of fibrous mats made by electrospinning and determines the effect of medicament on the fiber morphology, chemical, mechanical and thermal properties, as well as wettability. PCL and DSS-loaded PCL nanofibrous mats were characterized using scanning electron microscopy, transmission electron microscopy, attenuated total reflectance-Fourier transform infrared spectrometry, dynamic mechanical analysis, and contact angle measurements. Electron paramagnetic resonance measurements confirmed the lifetime of DSS before and after application of high voltage during the electrospinning process. In vitro biocompatibility was studied, and it was proved to be of good viability with ~92% of the diploid human cells culture line composed of lung fibroblast (MRC 5) after 48 h of incubation. Moreover, the significant activity of DSS-loaded nanofibers against cancer cells, Ca Ski and HeLa, was established as well. It was shown that 12.5% (m/V) is the minimal concentration for antibacterial activity when more than 99% of Escherichia coli (Gram-negative) and 99% of Staphylococcus aureus (Gram-positive) have been exterminated.

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Section: Discussionmentioning

confidence: 94%

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

et al. 2021

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“…Silica and PEG potentially affect the charge density of electrospun solutions, which directly affects the fiber diameter. In the relevant research [ 32 ], PEG showed lower electrical conductivity with a subsequently higher fiber diameter. Figure 2 demonstrates that the cationic nature of the encapsulated drug resulted in a larger fiber diameter compared with the ‘empty’ core PVA-PEG-SiO 2 and core–shell PVA-PEG-SiO 2 @PVA-GO.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel-Inducing Graphene-Oxide-Derived Core–Shell Fiber Composite for Antibacterial Wound Dressing

Kan

Bondareva

Statnik

et al. 2023

IJMS

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The study reveals the polymer–crosslinker interactions and functionality of hydrophilic nanofibers for antibacterial wound coatings. Coaxial electrospinning leverages a drug encapsulation protocol for a core–shell fiber composite with a core derived from polyvinyl alcohol and polyethylene glycol with amorphous silica (PVA-PEG-SiO2), and a shell originating from polyvinyl alcohol and graphene oxide (PVA-GO). Crosslinking with GO and SiO2 initiates the hydrogel transition for the fiber composite upon contact with moisture, which aims to optimize the drug release. The effect of hydrogel-inducing additives on the drug kinetics is evaluated in the case of chlorhexidine digluconate (CHX) encapsulation in the core of core–shell fiber composite PVA-PEG-SiO2-1x-CHX@PVA-GO. The release rate is assessed with the zero, first-order, Higuchi, and Korsmeyer–Peppas kinetic models, where the inclusion of crosslinking silica provides a longer degradation and release rate. CHX medicated core–shell composite provides sustainable antibacterial activity against Staphylococcus aureus.

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“…Drug release from a biodegradable carrier mainly occurs by polymer degradation or molecule diffusion thereby polymer properties are noteworthy to diversify drug release profile. For instance, diffusion of drugs is more expected instead of polymer degradation aided release in an aqueous medium for PCL due to its poor water solubility [69]. However, NF blend -MSN@ Cur100 lead a zero-order drug release profile, which allows the curcumin presence on the target area without any dose fluctuations.…”

Section: Curcumin Release and Msn Impairment Profiles From Nf Blend D...mentioning

confidence: 99%

Mesoporous silica nanoparticles accommodating electrospun nanofibers as implantable local drug delivery system processed by cold atmospheric plasma and spin coating approaches

Erdoğan,

Şen Karaman,

Yıldız

et al. 2024

Biomed. Mater.

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Nanofibers (NF) and nanoparticles are attractive in the field of drug delivery especially to improve the drug bioavailability and administration. Easy manipulation of polymeric fibers as macroscopic bulk material may give rise to potential uses as implantable local drug delivery platforms. In this study, poly(ethylene glycol) polyethyleneimine (mPEG: PEI) copolymer blended poly ε-caprolactone (PCL) nanofibers, NFblend accommodating mesoporous silica nanoparticles (MSN) as the implantable local drug delivery system was achieved by employing spin coating and cold atmospheric plasma (CAP) post-processing. The morphology and wettability, mechanical properties, and in vitro cytocompatibility features of NFblend ensured its features as a potential implantable local drug delivery system. The electron microscopy images affirmed the macropores on NFblend are still accessible and claimed the random nanofiber alignment of the NFblend after MSN accommodation may promote cell attachments. Furthermore, the drug release profile from the NFblend and in vitro cytocompatibility and scaffolding features for cell attachment were determined. The sustained drug release profile for 48h was provided regardless of MSN impairment from mat and bulk degradation. The accumulation of curcumin loaded MSN (MSN@Cur) onto NFblend by CAP-assisted spin coating promote cell proliferation compared to its non-treated counterparts. All in all, the obtained NFblend-MSN@Cur nanofiber mats have a high potential to be employed as an implantable local drug delivery system.

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Pcl/Peg Electrospun Fibers as Drug Carriers for the Controlled Delivery of Dipyridamole

Cited by 6 publications

References 34 publications

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

Hydrogel-Inducing Graphene-Oxide-Derived Core–Shell Fiber Composite for Antibacterial Wound Dressing

Mesoporous silica nanoparticles accommodating electrospun nanofibers as implantable local drug delivery system processed by cold atmospheric plasma and spin coating approaches

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