PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery

Gou, Maling; Wei, XiaWei; Men, Ke; Wang, Bilan; Luo, Feng; Zhao, Xinbing; Wei, Yuquan; Qian, Zhiyong

doi:10.2174/138945011795906642

Cited by 92 publications

(80 citation statements)

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“…Some drug delivery systems that employ a biodegradable polymer, such as nanoparticles delivering anticancer agents, are commercially available. PCL-PEG-PCL copolymers are biodegradable, easy to produce, have an amphiphilic character, and have strong potential application in drug delivery systems (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

HosseinDanafar

2016

Jundishapur J Nat Pharm Prod

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Background: Natural products derived from plants play a significant function in healthcare in many cultures, both ancient and modern. curcumin (CUR) is a chemical constituent of turmeric with anticancer activity, but its poor water solubility limits its use clinically. Methods: To improve the bioavailability and water solubility of curcumin, we synthesized five series of poly (caprolactone)-poly (ethylene glycol)-poly (caprolactone) (PCL-PEG-PCL) triblock copolymers. The structure of the copolymers was characterized by HNMR, FT-IR, DSC, and GPC techniques. The nanoparticles (NPs) were prepared using a solvent evaporation method. To achieve the best delivery system, we assigned the effect of the length of the copolymers' hydrophilic and hydrophobic chains on the encapsulation of hydrophobic CUR, performed entrapment efficiency and drug loading assignments, as well as evaluated the particle distribution and in vitro release using the direct dispersion method. Results: CUR was encapsulated with 71% and 83% efficiency in biodegradable nanoparticulate formulations, based on NP4 and NP5. Dynamic laser light scattering (DLS) indicated a particle diameter of 112 nm and 110 nm for NP4 and NP5, respectively. FT-IR and DSC analysis of the NPs showed that CUR was encapsulated into the NPs. The in vitro release experiments showed that NP5 controlled the release of CUR more effectively, with only 51% of CUR released after 120 hours. Conclusions:The results indicate the successful formulation of curcumin-loaded PCL-PEG-PCL nanoparticles and improved water solubility of curcumin, which may have potential application in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

HosseinDanafar

2016

Jundishapur J Nat Pharm Prod

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“…As known, in the ringopening copolymerization reaction to form PLGA, concentration, purity and molar ratio of monomer, the concentration of catalyst, reaction temperature and time, etc. wound influence the molecular weight of resulting PLGA and the monomer conversation-rate [27]. Herein, we fixed the molar ratio of D,L-lactide to glycolide (1 : 1) and the mass ratio of monomer (total amount of D,L-lactide and glycolide) to SN (1 : 1), and researched the effect of concentration of catalyst on the synthesis of PLGA@SN.…”

Section: Synthesis Of Plga@sn By In-situ Polymerization Methodsmentioning

confidence: 99%

Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

Zhang

Hao

et al. 2012

Chin. Sci. Bull.

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Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods, in-situ polymerization method and water in oil in water (W/O/W) double emulsion method, to coat a nanosized poly(lactic-co-glycolic acid) (PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle (PLGA@SN). The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.

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“…MPEG-PCL diblock copolymer with a designed molecular weight of 4000 was synthesized according to previous reports. 27,28 Female BALB/c mice (8-10 weeks old) were purchased from the Laboratory Animal Center of Sichuan University (Chengdu, China). All studies involving mice were approved by the Institute's Animal Care and Use Committee.…”

Section: Materials and Methods Materialsmentioning

confidence: 99%

“…[23][24][25] Poly(ε-caprolactone) (PCL)/poly(ethylene glycol) (PEG) copolymers are biodegradable, amphiphilic, and easy to produce, showing promising applications in drug-delivery systems. 26,27 Monomethoxy PEG (MPEG)-PCL is a diblock PCL/PEG copolymer; its molecular structure is shown in Figure 1B. The authors have previously used MPEG-PCL micelles to deliver curcumin, creating a novel curcumin formulation with potential application in colon cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Treating acute cystitis with biodegradable micelle-encapsulated quercetin

Gou¹,

Wang²

2012

IJN

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Intravesical application of an anti-inflammatory drug is an efficient strategy for acute cystitis therapy. Quercetin (QU) is a potent anti-inflammatory agent; however, its poor water solubility restricts its clinical application. In an attempt to improve water solubility of QU, biodegradable monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles were used to encapsulate QU by self-assembly methods, creating QU/MPEG-PCL micelles. These QU/MPEG-PCL micelles with DL of 7% had a mean particle size of ∼34 nm, and could release QU for an extended period in vitro. The in vivo study indicated that intravesical application of MPEG-PCL micelles did not induce any toxicity to the bladder, and could efficiently deliver cargo to the bladder. Moreover, the therapeutic efficiency of intravesical administration of QU/MPEG-PCL micelles on acute cystitis was evaluated in vivo. Results indicated that QU/ MPEG-PCL micelle treatment efficiently reduced the edema and inflammatory cell infiltration of the bladder in an Escherichia coli-induced acute cystitis model. These data suggested that MPEG-PCL micelle was a candidate intravesical drug carrier, and QU/MPEG-PCL micelles may have potential application in acute cystitis therapy.

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PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery

Cited by 92 publications

References 0 publications

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

Treating acute cystitis with biodegradable micelle-encapsulated quercetin

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