PCDD/PCDF multimedia exposure analysis for the Canadian population: Detailed exposure estimation

Birmingham, Brendan C.; Gilman, Andrew P.; Grant, Donald L.; Salminen, Juha‐Pekka; Boddington, M. J.; Thorpe, Beverley; Wile, I.; Toft, Peter; Armstrong, V.C.

doi:10.1016/0045-6535(89)90383-4

Cited by 57 publications

(20 citation statements)

References 3 publications

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“…In Canada at the time, a maximum allowable daily intake for PCDDs and PCDFs of 10 pg TEq/kg body weight was suggested, and a collaborative effort by the Canadian government was underway to develop national guidelines (16).…”

mentioning

confidence: 99%

Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake.

Schecter

Startin

Wright

et al. 1994

Environ Health Perspect

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Food, especially meat, milk, and fish, is the immediate source of almost all polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and dioxinlike compounds in the general population. To estimate intake of these highly toxic compounds, we performed congener-specific dioxin analyses for the first time on U.S. food for 18 dairy meat, and fish samples from a supermarket in upstate New York. 2,3,7,8 Tetrachlorodibenzo-p-dioxin (TCDD, "dioxin") toxic equivalents (TEqs) on a wet weight basis for the dairy products ranged for 0.04 to 0.7 ppt, meat TEqs ranged from 0.03 to 1.5 ppt, and fish TEqs ranged from 0.02 to 0.13 ppt. Previous human breast milk and infant formula analyses were used with the current preliminary food data to estimate a range of dioxin intake for Americans. Average daily food intake of TEqs for an adult weighing 65 kg was estimated to be between 0.3 and 3.0 pg/kg body weight, for a total of 18-192 pg TEq, using 1986 American consumption rates. Due to the relatively high level of PCDDs and PCDFs commonly found in human breast milk from American women and from women in other industrial countries, a nursing infant may consume an average of 35-53 pg TEq/kg body weight/day in its first year of life. This may be compared with the current U.S. EPA virtually safe dose of 0.006 pg TCDD/kg body weight per day over a 70-year lifetime based on an upper limit cancer risk of 10(-6), or the 10 pg/kg/day used by some European government agencies.

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mentioning

confidence: 99%

Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake.

Schecter

Startin

Wright

et al. 1994

Environ Health Perspect

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“…Canada was a pioneer in incineration of urban solid waste, and when the first works describing dioxins as possible human carcinogenic appeared, incinerators were improved, resulting in minor contamination. 14,15 649…”

Section: Discussionmentioning

confidence: 98%

Scientific production on tetrachloro-dibenzo-dioxins: A bibliometric study

2006

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Tetrachloro-dibenzo-dioxins were declared as human carcinogenic substances in 1997. Objective: to analyse the scientific production about tetrachloro-dibenzo-dioxins between 1976 and 2005.Solla Price and Bradford models were applied. Different aspects of papers were analysed. Impact factor of journals was studied.3484 articles were found. The number of articles published each year is fitted to Solla Price model.It has been shown the scientific literature dispersion. Specialisation of some journals of Nucleus and 1 st Bradford Zone has been shown.

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“…The occurrence of these POPs in animal fatty foods has been accounted to estimate the human exposure of most Europeans and North Americans (Birmingham et al, 1989;Fürst et al, 1990a;MAFF 1992;Theelen et al, 1993). As a consequence, the regulatory authorities of the EU have defined different PCDD, PCDF and PCB contamination threshold levels for the compliance of both marketed feeds and foods.…”

Section: Animal Fatty Foodsmentioning

confidence: 99%

A Critical Review about Human Exposure to Polychlorinated Dibenzo-p-Dioxins (PCDDs), Polychlorinated Dibenzofurans (PCDFs) and Polychlorinated Biphenyls (PCBs) through Foods

Fernández-González

Yebra-Pimentel

Martínez-Carballo

et al. 2013

Critical Reviews in Food Science and Nutrition

105

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Dioxins include polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and part of polychlorinated biphenyls (PCBs). Only the compounds that are chlorinated at the 2,3,7, and 8 positions have characteristic dioxin toxicity. PCDDs, PCDFs and PCBs accumulate in the food chain due to their high lipophilicity, high stability, and low vapor pressure. They are not metabolized easily; however their hydroxylated metabolites are detected in feces. They cause a wide range of endocrine disrupting effects in experimental animals, wildlife, and humans. Endocrine related effects of PCDDs, PCDFs and PCBs on thyroid hormones, neurodevelopment and reproductive development were referenced. In addition, some studies of contamination of foods, bioaccumulation, dietary exposure assessment, as well as challenges of scientific research in these compounds were reviewed.

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PCDD/PCDF multimedia exposure analysis for the Canadian population: Detailed exposure estimation

Cited by 57 publications

References 3 publications

Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake.

Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake.

Scientific production on tetrachloro-dibenzo-dioxins: A bibliometric study

A Critical Review about Human Exposure to Polychlorinated Dibenzo-p-Dioxins (PCDDs), Polychlorinated Dibenzofurans (PCDFs) and Polychlorinated Biphenyls (PCBs) through Foods

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