Abstract:Results: The endogenous thrombin potential (ETP) was significantly higher for Rip3 +/+ vs Rip3 À/À PPP (Fig 1). With the addition of recombinant RIP3 (rRIP3), ETP was enhanced in Rip3 À/À PPP. Furthermore, the addition of rRIP3 to Rip3 +/+ PPP was able to enhance its ETP. Using the RIP3 inhibitor GSK 0 843, the ETP of Rip3 +/+ PPP was significantly reduced compared with untreated plasma (Fig 1). There was no change in ETP when RIP3 inhibitors were used on Rip3 À/À PPP (Fig 1). Human PPP was also subjected to t… Show more
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