PBDE serum concentration and preschool maturity of children from Slovakia

Drobná, Beata; Fabišíková, Anna; Čonka, Kamil; Gago, František; Oravcová, Petra; Wimmerová, Soňa; Feiler, Marina Oktapodas; Šovčíková, Eva

doi:10.1016/j.chemosphere.2019.05.284

Cited by 25 publications

(7 citation statements)

References 32 publications

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“…Additionally, these findings are in line with our earlier report that perinatal PBDE‐47 exposure from before pregnancy to PND 21 at comparable dosage (1.0 and 10 mg/kg/day) produced poor performance in the MWM test 21 . More importantly, these data are in accord with the epidemiological research that PBDEs exposure during developmental periods is related to delayed mental and motor development, as well as declined mental ability and attention deficit in the preschool stage 22,23 . Overall, our findings provide additional evidence that PBDEs are developmental neurotoxicants.…”

Section: Discussionsupporting

confidence: 92%

“…21 More importantly, these data are in accord with the epidemiological research that PBDEs exposure during developmental periods is related to delayed mental and motor development, as well as declined mental ability and attention deficit in the preschool stage. 22,23 Overall, our findings provide additional evidence that PBDEs are developmental neurotoxicants.…”

Section: Discussionsupporting

confidence: 57%

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Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis

Dong

Sun

Qiu

et al. 2023

Journal of Pineal Research

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The neurotoxicity of 2,2’,4,4’‐tetrabromodiphenyl ether (PBDE‐47) is closely linked to mitochondrial abnormalities while mitophagy is vital for mitochondrial homeostasis. However, whether PBDE‐47 disrupts mitophagy contributing to impaired neurodevelopment remain elusive. Here, this study showed that neonatal PBDE‐47 exposure caused learning and memory deficits in adult rats, accompanied with striatal mitochondrial abnormalities, neuronal apoptosis and the resultant neuronal loss. Mechanistically, PBDE‐47 suppressed PINK1/Parkin‐mediated mitophagy induction and degradation, inducing mitophagosome accumulation and mitochondrial dysfunction in vivo and in vitro. Additionally, stimulation of mitophagy by adenovirus‐mediated Parkin or Autophagy‐related protein 7 (Atg7) overexpression aggravated PBDE‐47‐induced mitophagosome accumulation, mitochondrial dysfunction, neuronal apoptosis and death. Conversely, suppression of mitophagy by the siRNA knockdown of Atg7 rescued PBDE‐47‐induced detrimental consequences. Importantly, melatonin, a hormone secreted rhythmically by the pineal, improved PBDE‐47‐caused neurotoxicity via preventing neuronal apoptosis and loss by restoring mitophagic activity and mitochondrial function. These neuroprotective effects of melatonin depended on activation of the AMP‐activated protein kinase (AMPK)/Unc‐51‐like kinase 1 (ULK1) signaling. Collectively, these data indicate that PBDE‐47 impairs mitophagy to perturb mitochondrial homeostasis, thus triggering apoptosis, leading to neuronal loss and consequent neurobehavioral deficits. Manipulation of the AMPK‐mitophagy axis via melatonin could be a novel therapeutic strategy against developmental PBDE‐47 neurotoxicity.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 57%

Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis

Dong

Sun

Qiu

et al. 2023

Journal of Pineal Research

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“…As reported, both occurrence and distribution of PBDEs are different in blood, resulting from the differences in region, age, occupation, and gender. Generally, PBDEs are always at the level of ng/mL or ng/g in serum, with BDE-47, BDE-99, BDE-100, BDE-153, and BDE-209 as main con-geners [9][10][11][12][13]. Owing to the abundant presence of endogenous substances (proteins and lipids) in serums, especially fatty acids, phospholipids, cholesterols, steroid hormones, the trace analysis of PBDEs in serum is facing challenges in removing such endogenous substances [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A cleanup method of serum extracts with molecular sieves as SPE sorbents for the analysis of polybrominated diphenyl ethers

Liu

Jin

Xue³

et al. 2022

J of Separation Science

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Based on the size-and shape-selective sorption, 13X molecular sieves were developed as solid-phase extraction adsorbents to cleanup serum extract for the determination of polybrominated diphenyl ethers. The important parameters affecting the cleanup efficiency were investigated including the amount of sorbents, the type, and volume of solvents. Under the optimized conditions, the capacity for removing impurities was evaluated via gel permeation chromatography and gas chromatography with mass spectrometry. The results demonstrated that up to 99% of lipids in corn oil (13 mg) can be removed after cleanup, and endogenous compounds in serum can also be effectively eliminated. The cleanup efficiency is not only superior to hydrophile-lipophile balance column, but also close to acid silica gel and multifunction impurity sorbents. Generally, the developed cleanup method exhibited higher recovery for polybrominated diphenyl ethers with more than four bromines, especially for nona-and deca-brominated diphenyl ethers (99.1˗117.8%). The cleanup method can be coupled with gas chromatography and tandem mass spectrometry for polybrominated diphenyl ethers analysis in human serum. The method detection limits were 0.01˗0.27 ng/mL and average recovery was 50.9˗113.

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“…Children have been shown to be the social group the most strongly affected by exposure to PBDEs, and adverse health effects impact prenatal and small children particularly strongly (Vuong et al 2018a, b, c). PBDEs have been reported to act as endocrine disruptors (Ji et al 2019;Vuong et al 2018a, b, c) and can cause neurological defects (Drobna et al 2019), permanent learning and memory impairment (Cowell et al 2018), behavioural changes (Vuong et al 2017(Vuong et al , 2018a, hearing defects (Fabelova et al 2019), delayed onset of puberty (Harley et al 2017), decreased sperm count (Zhang et al 2020), foetal malformations (Koren et al 2019), and, possibly, cancer (Hoffman et al 2017). The main routes of exposure to PBDEs are the oral route, with the most significant sources listed as: dust, meat and dairy products (Śmiełowska and Zabiegała 2020;Pietron et al 2021;Zacs et al 2021;Konstantas et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Small Polymeric Toys Placed in Child-Dedicated Chocolate Food Products—Do They Contain Harmful Chemicals? Examination of Quality by Example of Selected VOCs and SVOCs

2021

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This study was focused on child-dedicated chocolate food products that contain a plastic package with a small toy inside (also known as chocolate eggs). Three types of these products that are commercially available on the Polish market, with different prices, chocolate composition, and main types of polymers used in the toy manufacturing process, were investigated. The polymers were identified using Fourier-transform infrared (FT-IR) analysis and emissions of selected toxic volatile organic compounds of toy and packaging samples were identified using stationary emission micro-chamber. Total volatile organic compounds emissions were also estimated. Moreover, the content of polybrominated diphenyl ethers (PBDEs) as bioaccumulative semi-volatile organic compounds was checked in all parts of the cheapest product. The highest PBDE concentrations, which ranged from 5.32 ± 0.79 to 1768 ± 289 ng/g, were recorded in chocolate samples. This demonstrates the need for consumer knowledge on the safety of such products available on the Polish market to be broadened. This is one of the many examples of studies showing that products sold on the European market do not always comply with the Conformité Européenne (CE) declaration of conformity. Furthermore, the presence of phased-out PBDEs in toys may provide evidence of wrong recycling practices. Forward-looking considerations showed that, based on assessments of the hazard quotient (HQ) and cancer risk of BDE-209 and assuming each child has contact with one toy and eats one of the studied chocolate products per day, there is no high risk associated with the exposure of children to PBDEs.

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PBDE serum concentration and preschool maturity of children from Slovakia

Cited by 25 publications

References 32 publications

Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis

Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis

A cleanup method of serum extracts with molecular sieves as SPE sorbents for the analysis of polybrominated diphenyl ethers

Small Polymeric Toys Placed in Child-Dedicated Chocolate Food Products—Do They Contain Harmful Chemicals? Examination of Quality by Example of Selected VOCs and SVOCs

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