Pb2397: Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Expressing Myd88 L265p Reveals Cd44, Lgals3, Nfkbiz and Batf as Downstream Targets of Oncogenic Nf-Κb Signaling.

Abstract

Background:Myeloid differentiation primary response 88 (MyD88) serves as a crucial signaling adaptor protein during innate immune responses, integrating stimuli from the Toll-like receptors (TLR) and Interleukin-1 receptor (IL-1R) family and translating them into specific cellular outcomes. In B cells, somatic mutations of MyD88 induce oncogenic NFκ B signaling independently of receptor stimulation, resulting in the onset of B-cell malignancies. However, the precise molecular mechanisms and downstream signaling targets remain unresolved.