Pb2058 the Prognostic Role of Myocyte‐specific Enhancer Factor 2 c (Mef2 c) in Patients With Diffuse Large B‐cell Lymphomas (Dlbcl)

Abstract

Background: Lymphomas are relatively common tumors that may affect the orbit through tissue infiltration. However, data available about tumors possibly originating in orbit (also called orbital lymphoma) are scarce. Aims: In this study, we aimed to spotlight on this type of malignancy using the using data from American National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) Program. Methods: We used SEER * Stat version 8.3.5, Microsoft Excel, as well as SPSS IBM SPSS Statistics for Windows, Version 25.0 for data analysis. In SEER * Stat, we used the (Incidence -SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2017 Sub (1973-2015) database to obtain data. We included cases diagnosed with lymphoma between 2006 and 2015 at site related to orbital cavity C69.0-C69.9. Results: A total of 2340 cases were identified with a median age of 65.2. Females and patients of white race represented the majority of the analyzed cohort (n = 1249, 53.4%; n = 1846, 78.9%, respectively). Age-adjusted Incidence rate was 3 per 10,000. 5-years observed survival was 82 % (95% CI: 79.8% -84%) while the 5-years relative survival was 94.3 % (95% CI: 91.3% -96.2%). The most common pathology of studied cases was extranodal marginal zone lymphoma of mucosal-associated lymphoid tissue (MALT) (n = 1310, 56%) [Table 1]. Median survival was not reached at the study cutoff (Figure 1).