Pb(II) Complexes of Schiff Bases Derived from Benzoylhydrazine as the Antibacterial Agents

Uddin, Mohammad Nasir

doi:10.11648/j.mc.s.2015030101.12

Cited by 14 publications

(2 citation statements)

References 17 publications

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“…The azomethine proton signal in the spectrum of the corresponding complex is shifted downfield compared to the free ligand, suggesting the deshielding of the azomethine group due to the coordination with the metal ion. 15 The peak appeared at 9.6 δ (singlet) is due to the hydrogen of -NH in the ligand, but in case of Zn(II) complex the peak was observed at 9.6 δ (singlet). 16 The phenyl multiplet is seen at 6.5 -7.4 δ, but in Zn(II) complex multiplet is seen at 6.9 -7.8 δ.…”

Section: H-nmr Spectral Studiesmentioning

confidence: 97%

Untitled

2016

IJPSR

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New tetradentate Schiff base and its Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes formed by the condensation of 5-fluoro-3-hydrazonoindolin-2-one with isophthalaldehyde. The coloured complexes were prepared of [MLX 2 ], Where L = Schiff base hydrazone, M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), X = Cl-. Physico-chemical characterization has been carried out to determine the structure of the complexes. All the synthesized compounds, were studied for their in vitro antibacterial, and antifungal activities, against two Gram-negative (Shigella flexneri and Enterococcus aerogens) and one Gram-positive (Micrococcus luteus,) bacterial strains and against three fungal strains (Candida krusiae Candida parasilopsis and Malassesia pachydermatis) by using cup-plate method. The DNA cleavage capacity of all the complexes was analysed by agarose gel electrophoresis method.

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Section: H-nmr Spectral Studiesmentioning

confidence: 97%

Untitled

2016

IJPSR

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“…39.8-39.59(C1andC2 *Corresponding author: skathim@uowasit.edu.iq https://wjps.uowasit.edu.iq/index.php/wjps/index phenylene diamine) it has Its infrared spectrum showed a double-headed band at wavenumbers 3201-3306, belonging to the stretching of the symmetrical and asymmetric N-H bond, respectively [14]. Comparing the spectrum of the two primary substances with the spectrum of compounds showed the appearance of new bands and the disappearance of other bands, as the double-headed band disappeared at The wave number (3306-3201) due to the stretching of the N-H bond is evidence of the loss of proton, the disappearance of the stretch band (C=O) at 1625 cm-1, and the appearance of a new band at the wave number(1589 cm-1)A,(1552 cm-1) B,(1550 cm-1) C due to the stretching of the C=N bond [15]as well as the appearance of a band at( 3419,3422,3446) dating back to the stretching of the OH bond. [16].…”

Section: Characterizationmentioning

confidence: 97%

Inhibitory Activity of 4-(Dimethyl amino) benzaldehyde Schiff Bases: Synthesis and Characterization

Hamid

2023

wjps

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Some new Ag(I), VO(II) and Pd(II) chelates incorporating tridentate imine ligand: Design, synthesis, structure elucidation, density functional theory calculations for DNA interaction, antimicrobial and anticancer activities and molecular docking studies

Abdel‐Rahman

Abu‐Dief

Shehata

et al. 2019

Applied Organom Chemis

112

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Some new complexes derived from VO(II), Ag(I) and Pd(II) metal ions and HNA imine ligand (L), i.e. (2‐((6‐allylidene‐2‐hydroxycyclohexa‐1,3‐dienylmethylene)amino)benzoic acid), have been prepared and their structures elucidated via molar conductance measurements, elemental analyses, infrared, NMR and electronic spectra and magnetic susceptibility estimations. Moreover, stability constants of the synthesized complexes were evaluated utilizing a spectrophotometric technique. On the basis of molar conductance and elemental analyses, the metal imine chelates have structure [M(L)], where M = Pd(II), VO(II) and Ag(I). The results indicate that the prepared HNA imine ligand acts as a tridentate moiety via nitrogen atom of azomethine group and two oxygen atoms of phenolic and carboxylic groups. All the complexes are found to be monomeric with 1:1 stoichiometry with square planar geometry for Pd(II), tetrahedral geometry for Ag(I) and distorted square pyramidal for VO(II). Theoretical density functional theory calculations were applied to verify the molecular geometry of the chelators and their metal chelates. The geometry optimization results are in agreement with experimental observations. The antimicrobial properties of the prepared HNA imine ligand and its metal chelates were evaluated against numerous plant pathogenic fungi and bacteria. The results of these studies indicate that the metal complexes exhibit a stronger antibacterial and antifungal effect compared to the imine ligand. In addition, the interaction of the metal imine chelates with calf thymus DNA was observed by way of viscosity, gel electrophoreses and spectral studies. Absorption titration studies reveal that each of the complexes is an avid binder to calf thymus DNA. Also, there are appreciable changes in the relative viscosity of DNA, which are consistent with enhanced hydrophobic interaction of the aromatic rings and intercalation mode of binding. Additionally, the cytotoxic activity of the investigated compounds against various cancer cell lines shows promising results which makes them prospective compounds for antibiotic and anticancer medicament studies. Furthermore, docking studies of the prepared compounds were conducted for confirming the biological results.

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Pb(II) Complexes of Schiff Bases Derived from Benzoylhydrazine as the Antibacterial Agents

Cited by 14 publications

References 17 publications

Untitled

Untitled

Inhibitory Activity of 4-(Dimethyl amino) benzaldehyde Schiff Bases: Synthesis and Characterization

Some new Ag(I), VO(II) and Pd(II) chelates incorporating tridentate imine ligand: Design, synthesis, structure elucidation, density functional theory calculations for DNA interaction, antimicrobial and anticancer activities and molecular docking studies

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