Pay-it-forward to improve influenza vaccine uptake and public engagement among children and older adults in China: A quasi-experimental pragmatic trial

Wu, Dan; Jin, Chenqi; Bessame, Khaoula; Tang, Fanny Fong-Yi; Ong, Jason J.; Wang, Zaisheng; Xie, Yewei; Jit, Mark; Larson, Heidi J.; Chantler, Tracey; Lin, Leesa; Gong, Wenfeng; Yang, Fan; Jing, Fengshi; Wei, Shufang; Cheng, Weibin; Zhou, Yi; Ren, Nina; Qiu, Shuhao; Bao, Jinxiao; Wen, Liufen; Yang, Qinlu; Jian-guo, Tian; Tang, Weiming; Tucker, Joseph D.

doi:10.1101/2021.10.30.21265713

Cited by 1 publication

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The parent intervention study took place between September 2020 to February 2021 in Guangdong Province of Southern China where in uenza is prevalent throughout the year (31). The study design has been described in detail in a preprint (30). Three clinics with relatively stable availability of in uenza vaccines were chosen as study sites.…”

Section: Study Settings and Participantsmentioning

confidence: 99%

“…Participants in all three arms received introductory pamphlet about in uenza and vaccination. The intervention study aimed to compare the effectiveness between pay-it-forward and standard-of-care in in uenza vaccine uptake among children and older people, with the free vaccination arm not being powered to test the differences and serving the purpose for costs comparison (30). The pay-it-forward model is depicted in Appendix Figure A1.…”

Section: Parent Study Design and Data Collectionmentioning

confidence: 99%

“…Second, statistically, the sample size calculation was not powered to test differences between free-of-charge and the other two arms in the parent study. The free-of-charge arm only served a purpose for costs evaluation (30).…”

Section: Regrouping Study Arms For the Secondary Data Analysismentioning

confidence: 99%

“…This is a secondary data analysis of a parent quasi-experimental study (trial registration: ChiCTR2000040048) in which the effectiveness of a pay-it-forward intervention in improving in uenza uptake in children and older people was assessed against a standard-of-care arm. Pay-it-forward has an individual to receive a free vaccine pre-paid by others in the community and offers the individual an opportunity to donate to support subsequent people to receive the same service [30]. An additional free arm was included in the parent study primarily for costs comparison.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influenza vaccine uptake among children and older adults in China: A secondary analysis of a quasi-experimental study

Jin²,

Jit

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Influenza vaccination is the key to reducing the influenza-related disease burden, especially among high-risk populations. However, influenza vaccine uptake is low in China. This secondary analysis of a quasi-experimental trial in Guangdong Province aimed to understand factors associated with influenza vaccine uptake among children and older people stratified by funding context. Methods: A total of 225 children (aged 0.5-8 years) and 225 older people (aged 60 years or above) were recruited from three clinics (rural, suburban, urban). Participants were allocated into two groups based on different funding contexts: self-paid group (N=150, including 75 children and 75 older adults) in which participants paid full market price for their vaccination; and subsidized group (N=300, including 150 children and 150 older adults) in which varying levels of financial support was provided. Univariable and multivariable logistic regressions were conducted stratified by funding contexts. Results: Overall, 75.0% (225/300) of participants in the subsidized group and 36.7% (55/150) in the self-paid group got vaccinated. Older adults had lower vaccination rates than children in both funding groups, while both age groups showed much higher uptake in the subsidized group than in the self-paid group (86.7% vs 53.3% among children; 63.3% vs 20.0% among older people). In the self-paid group, participants living with children (aOR:2.61, 95%CI: 1.06-6.42) or older people (aOR:4.76, 95%CI: 1.08-20.90) having prior influenza vaccination in the same household were more likely to be vaccinated; trust in providers’ advice (aOR=4.95, 95%CI:1.99, 12.43) or effectiveness of the vaccine (aOR: 12.18, 95%CI: 5.21-28.50), and experienced influenza-like illnesses in the family (aOR=46.52, 4.10, 533.78) were associated with higher vaccine uptake in the subsidized group. Conclusions: Older people had suboptimal vaccine uptake compared to children in both contexts and need more attention in future efforts to enhance influenza vaccination. Tailoring interventions to different vaccine funding contexts may help improve influenza vaccine uptake: In self-paid context, measures to motivate people to accept their first ever influenza vaccination may be a promising strategy. In subsidized context, strategies to improve public confidence in vaccine effectiveness and providers’ advice would be useful. Trial registration: ChiCTR2000040048. Registered on November 19, 2020.

show abstract

Section: Study Settings and Participantsmentioning

confidence: 99%

Section: Parent Study Design and Data Collectionmentioning

confidence: 99%

Section: Regrouping Study Arms For the Secondary Data Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations