PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer

Xia, Xianghou; Yin, Wenjuan; Zhang, Xiping; Yu, Xiao Fang; Wang, Chen; Xu, Shumin; Feng, Wenjie; Yang, Huanming

doi:10.3892/ol.2015.3434

Cited by 20 publications

(22 citation statements)

References 22 publications

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“…For example, PAX6 is overexpressed in breast cancer tissues and cell lines. Breast cancer patients with an increased expression level of PAX6 exhibited poorer prognosis than those with a decreased PAX6 level (36). PAX6 knockdown was revealed to inhibit cell viability, proliferation, colony formation and metastasis in vitro and decrease tumour growth in vivo (37,38).…”

Section: Discussionmentioning

confidence: 98%

MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

You

2018

Oncol Rep

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Accumulated studies have highlighted that the dysregulation of microRNAs (miRNAs) in retinoblastoma (RB) is a leading cause for tumourigenesis and tumour development. Therefore, the elucidation of the expression, functional roles and underlying mechanisms of miRNAs in RB will help the development of promising therapeutic methods to improve the prognosis of RB patients. The aim of this study was to detect miRNA‑758 (miR‑758) expression in RB tissues and cell lines, and to determine the effects and underlying mechanisms of miR‑758 on RB progression. The results demonstrated that miR‑758 was downregulated in both RB tissues and cell lines. In vitro functional experiments revealed that upregulation of miR‑758 inhibited cell proliferation, migration and invasion, and induced apoptosis in RB. In addition, paired box protein 6 (PAX6) was a direct target gene of miR‑758 in RB. Furthermore, PAX6 was upregulated in RB tissues, and this upregulation was inversely associated with the expression level of miR‑758. In addition, PAX6 reintroduction abrogated the tumour‑suppressive effects of miR‑758 overexpression on RB cell proliferation, migration, invasion and apoptosis. Furthermore, miR‑758 overexpression inactivated the PI3K/Akt pathway in RB cells by inhibiting PAX6. In conclusion, our current study provided sufficient evidence to demonstrate that miR‑758 inhibits the progression of RB by directly targeting PAX6 and regulating the PI3K/Akt pathway, thereby suggesting that this miRNA may be developed as a therapeutic target for treating patients with RB.

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Section: Discussionmentioning

confidence: 98%

MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

You

2018

Oncol Rep

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“…PAX6, a member of the PAX gene family, serves as a key regulator in the development of eyes, central nervous system and pancreas (36,37). PAX6 was found to be expressed at elevated levels in in several types of human cancer, including colorectal cancer (38), retinoblastoma (39), breast cancer (40) and non-small cell lung cancer (41). Furthermore, deregulated PAX6 is implicated in the regulation of tumor formation and progression through regulating cell proliferation, cell cycle, apoptosis, migration and invasion (38,39,42).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑874 inhibits proliferation and invasion of pancreatic ductal adenocarcinoma cells by directly targeting paired box 6

Diao

Cao

et al. 2018

Mol Med Report

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Studies have demonstrated that a number of microRNAs (miRNAs) are dysregulated in pancreatic ductal adenocarcinoma (PDAC), and alterations in their expression may affect the onset and progression of PDAC. Therefore, the expression patterns, biological functions and associated molecular mechanisms of miRNAs in PDAC should be elucidated for the development of novel therapeutic methods. Previous studies reported significant miRNA‑874 (miR‑874) dysregulation in multiple types of human cancer. However, the expression pattern, possible roles and underlying mechanisms of miR‑874 in PDAC remain to be elucidated. This study evaluated miR‑874 expression in PDAC and examined its biological functions and underlying mechanism of action in PDAC progression. miR‑874 expression was downregulated in PDAC tissues and cell lines. Functional experiments demonstrated that upregulation of miR‑874 inhibited cell proliferation and invasion in PDAC. Additionally, paired box 6 (PAX6) was predicted as a putative target of miR‑874 using bioinformatics analysis. Further experiments demonstrated that PAX6 may be the direct target gene of miR‑874 in PDAC. PAX6 knockdown exhibited similar inhibitory effects to miR‑874 overexpression in PDAC cells. In addition, restored PAX6 expression may reverse the suppressive roles of miR‑874 overexpression in PDAC cells. The results demonstrated that miR‑874 may serve tumor suppressive roles in PDAC by directly targeting PAX6. Therefore, miR‑874 may exhibit potential applications for treatment of patients with PDAC.

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“…PAX6, a highly conserved transcription factor, contributes to the development of tissues, including those of the eyes, in the central nervous system and in endocrine glands of vertebrates and invertebrates (39,40). PAX6 is upregulated in various types of human cancers, such as gastric cancer (41), lung cancer (42), breast cancer (43) and retinoblastoma (44).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-383 suppresses cell proliferation and invasion in colorectal cancer by directly targeting paired box 6

Fang

Duan

et al. 2018

Mol Med Report

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Colorectal cancer (CRC) is the third-most prevalent cancer and the fourth‑most common cause of cancer-associated fatality worldwide. The expression and biological roles of microRNAs (miRNAs/miRs) in tumourigenesis, and their regulatory function in a number of biological processes correlated with cancer have been investigated. miR‑383 has been reported to be deregulated in several human cancer types. However, the involvement and effects of miR‑383 on CRC progression and its underlying mechanism remain unknown. Therefore, the present study aimed to examine miR‑383 expression, investigate the biological functions of miR‑383 and identify its mechanism of action in CRC cells. In the present study, miR‑383 was significantly downregulated in CRC tissues and cell lines. Low miR‑383 expression was negatively associated with tumour size, lymph node metastasis and TNM stage. Function experiments demonstrated that miR‑383 upregulation inhibited the proliferation and invasion of CRC cells. Paired box 6 (PAX6) was confirmed as a direct target of miR‑383. PAX6 was upregulated in CRC tissues and was negatively correlated with miR‑383 expression. Induced PAX6 overexpression effectively rescued the tumour‑suppressing roles of miR‑383 on CRC cell proliferation and invasion. These findings suggested that miR‑383 may act as a tumour suppressor in CRC by directly targeting PAX6 and may serve as a promising therapeutic target for CRC treatment.

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PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer

Cited by 20 publications

References 22 publications

MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

MicroRNA‑874 inhibits proliferation and invasion of pancreatic ductal adenocarcinoma cells by directly targeting paired box 6

MicroRNA-383 suppresses cell proliferation and invasion in colorectal cancer by directly targeting paired box 6

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