Pax6 Is Required for Making Specific Subpopulations of Granule and Periglomerular Neurons in the Olfactory Bulb

Kohwi, Minoree; Osumi, Noriko; Rubenstein, John L.R.; Alvarez-Buylla, Arturo

doi:10.1523/jneurosci.1435-05.2005

Cited by 298 publications

(326 citation statements)

References 40 publications

(52 reference statements)

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“…In contrast, the production of CR-and TH-expressing PG cells follows an opposite trend with a progressive increase with age (De Marchis et al 2007 ). According to previous studies (Hack et al 2005 ;Kohwi et al 2005 ;Waclaw et al 2006 ) this work suggests that the population of SVZ progenitors with a PG fate is composed of a heterogeneous pool of neurochemically specified elements, and indicates that the relative contribution of these different subsets changes with time. Therefore, neurogenesis in the OB does not reflect a simple turnover of the whole interneuron population of the GL, but it may serve to finely modulate the relative amounts of distinct OB interneuron subpopulations.…”

Section: Temporal Differences In the Generation Of Ob Interneuron Subsupporting

confidence: 51%

“…Indeed, Pax6 expression in RMS precursor cells is required to progress towards a PG neuron subtype and its target deletion strongly reduces the proportion of PG cells normally generated (Hack et al 2005 ). Moreover, Pax6 governs the specific differentiation of dopaminergic periglomerular and superficial granule cells in the adultOB (Hack et al 2005 ;Kohwi et al 2005 ). Pax6 is expressed in most proliferating SVZ progenitors but only in a subpopulation of migrating neuroblasts, further indicating that migrating neuroblasts are heterogeneous.…”

Section: Specification Of the Different Ob Interneuronal Phenotypesmentioning

confidence: 99%

“…Pax6 is expressed in most proliferating SVZ progenitors but only in a subpopulation of migrating neuroblasts, further indicating that migrating neuroblasts are heterogeneous. Transplantation of GFP-positive dLGE precursors from Pax6 knock-out mice into wild-type adult SVZ environment produce neuroblasts capable of migrating into the OB but fail to generate dopaminergic periglomerular and superficial granule cells (Kohwi et al 2005 ). Moreover, Pax6 overexpression in both SVZ and RMS is sufficient to induce differentiation of PG cells toward dopaminergic phenotypes (Hack et al 2005 ).…”

Section: Specification Of the Different Ob Interneuronal Phenotypesmentioning

confidence: 99%

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Spatio-temporal specification of olfactory bulb interneurons

et al. 2007

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Olfactory bulb (OB) interneurons are continuously generated throughout development and in adulthood, and are derived from different progenitor zones. Once integrated in the OB circuits, interneurons play essential roles in olfactory information processing by modulating the activity of major output neurons. These functions are performed by multiple classes of neurons that differ in their spatial distribution, morphology, neurochemical and synaptic properties. This diversity, and the continuous neurogenesis make the understanding of the specification mechanisms in the OB a challenging task. New studies suggest that both intrinsic and extrinsic cues are involved in fate determination of OB interneurons. In both development and adulthood the expression of specific transcription factors not only defines different progenitor regions but also precise interneuronal phenotypes. Here we discuss recent findings on the molecular mechanisms regulating production and diversity of OB interneurons with respect to the spatial and temporal parameters.

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Section: Temporal Differences In the Generation Of Ob Interneuron Subsupporting

confidence: 51%

Section: Specification Of the Different Ob Interneuronal Phenotypesmentioning

confidence: 99%

Section: Specification Of the Different Ob Interneuronal Phenotypesmentioning

confidence: 99%

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Spatio-temporal specification of olfactory bulb interneurons

et al. 2007

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“…In addition, forced expression of Pax7 in satellite cells prevents their difference into myoblasts (Olguin and Olwin, 2004). Similarly the activity of Pax6 is involved in conferring progenitor status to neuronal populations in the spinal cord, cerebral cortex, adult hippocampus, and olfactory bulb (Grindley et al, 1995;Kohwi et al, 2005;Bel-Vialar et al, 2007;Tucker et al, 2008). Similarly, the expression of Pax2 and Pax8 is associated with proliferating progenitor populations in the developing kidney (Bouchard et al, 2002) and in the sensory patches of the inner ear (Li et al, 2004;Warchol and Richardson, 2009).…”

Section: Control Of Cell Division By Pax2mentioning

confidence: 99%

Pax2 modulates proliferation during specification of the otic and epibranchial placodes

Freter¹,

Muta²,

O’Neill³

et al. 2012

Developmental Dynamics

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Background: The inner ear and epibranchial ganglia of vertebrates arise from a shared progenitor domain that is induced by FGF signalling, the posterior placodal area (PPA), before being segregated by Wnt signalling. One of the first genes activated in the PPA is the transcription factor Pax2. Loss-of-and gain-of function studies have defined a role for Pax2 in placodal morphogenesis and later inner ear development, but have not addressed the role Pax2 plays during the formation and maintenance of the PPA. Results: To understand the role of Pax2 during the development of the PPA, we used over-expression and repression of Pax2. Both gave rise to a smaller otocyst and repressed the formation of epibranchial placodes. In addition, cell cycle analysis revealed that Pax2 suppression reduced proliferation of the PPA. Key FindingsNeither suppression nor over-expression of Pax2 affects the extent of the precursor region of the inner ear and epibranchial placodes, the PPA. Suppressing and over-expressing Pax2 does affect the differentiation of the inner ear and the epibranchial placodes. Pax2 suppression reduces proliferation of PPA precursors.

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“…Cependant, il a été montré récemment que le morphogène Sonic hedgehog est impliqué dans ce processus et contrôle le devenir des cellules souches situées dans la partie ventrale de la paroi ventriculaire [3]. Une protéine clé pour la génération des neurones dopaminergiques du cerveau antérieur est le facteur de transcription Pax6 (paired box 6) [4,5]. De plus, il a été montré que l'action de ce facteur est clairement dépendante de sa concentration, notamment dans sa fonction de déterminant dopaminergique [6].…”

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