PAX2 Expression in Endometrial Intraepithelial Neoplasia

Abstract

Endometrial intraepithelial neoplasia (EIN) is a clonal growth of glands of the endometrium, regarded as a precancerous condition because of its highcorrelation with endometrioid adenocarcinoma of the endometrium of uterus.Objective: To evaluate the expression of PAX2 in EIN and to correlate the expression with clinical parameters. Materials and Methods:-This is a retrospective study for (57)totalcasesof D&C and endometrial pipple biopsies, (21) cases where diagnosed as hormonal imbalance, (26) cases where diagnosed as EIN and (10) cases where diagnosed as endometrioid endometrial adenocarcinoma.Results: -Total number of cases that showed completely loss of PAX2 expression in all this study groups 25/57 and cases that showed partial loss 10/57. In hormonal imbalance group: all the cases showed normal expression of PAX2. In EIN: (65.4%) of cases were with complete loss of PAX2, (30.4%) with partial loss. In endometrial endometrioid cancer group:80% of cases with complete PAX2 expression, while partial loss or decrease PAX2 expression did occur in only (20%) ofcases.The association between study groups and PAX2 expression:decrease and complete loss of PAX2 staining were significantly (P= 0.001) occurred in cases of EIN and endometrial endometroid adenocarcinoma, while there was insignificant association (P=0.635) between study groups (EIN and endometrial endometroid adenocarcinoma), and results of PAX2 expression. Conclusion:-Loss of PAX2 immunomarkerexpressionhappens early and during of EIN using the WHO diagnostic categories.