PAX-2: A Developmental Gene Constitutively Expressed in the Mouse Epididymis and Ductus Deferens

Oefelein, Michael G.; Grapey, David; Schaeffer, Theodore; Chin-Chance, Catherine; Bushman, Wade

doi:10.1016/s0022-5347(01)65751-3

Cited by 22 publications

(11 citation statements)

References 16 publications

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“…We found that AmphiPax2/5/8 was expressed in the testis and tail. Similarly in vertebrates, early discoveries disclosed the expression of Pax2 in the vas deferens and epididymis [30,31], and the expression of Pax5 in both the testis and chordoneural hinge region of the tail [32,33]. Integratively considering all of these observations, we presume that AmphiPax2/5/8 is a multi-function gene in amphioxus and it is subfunctionalized after gene duplication in vertebrates.…”

Section: Conserved Roles Of Pax2/5/8 Subfamily Genesmentioning

confidence: 74%

Spatiotemporal expression of Pax genes in amphioxus: Insights into Pax-related organogenesis and evolution

Chen

Zhang

Wang

et al. 2010

Sci. China Life Sci.

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The expression of four AmphiPax genes in 16 developmental stages and different organs in amphioxus (Branchiostoma belcheri) was investigated, finding those genes expressed throughout amphioxus life with temporal-specific (especially during embryogenesis and metamorphosis) and spatial-specific patterns. This study suggests that duplicated Pax genes in vertebrates might maintain most of their ancestral functions and also expand their expression patterns after the divergence of protochordates and vertebrates.

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Section: Conserved Roles Of Pax2/5/8 Subfamily Genesmentioning

confidence: 74%

Spatiotemporal expression of Pax genes in amphioxus: Insights into Pax-related organogenesis and evolution

Chen

Zhang

Wang

et al. 2010

Sci. China Life Sci.

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“…aquaporin-1 with its role in fluid resorption, it would appear that epididymal epithelial cells have defined functions prior to birth (Fisher et al, 1998). Null mutation and tissue distribution studies have indicated that normal development of the epididymis during gestation is crucially dependent on the presence of several genes, including the growth factor Bmp8a (Zhao et al, 1998), the oncogene e-ros (Sonnenberg-Riethmacher et al, 1996), the paired box gene Pax-2 (Oefelein et al, 1996), and the homeobox domain related genes, Hox family of genes (Podlasek et al, 1999;Lindsey et al, 1996), and Pem2 (Sutton et al, 1998). …”

Section: Differentiation: the Formation Of The Epididymal Ductmentioning

confidence: 99%

The Coming of Age of the Epididymis

Robaire¹,

Syntin²,

Jervis³

2000

Testis, Epididymis and Technologies in the Year 2000

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“…As in the Wolffian tubes and the developing kidneys, 16,17 PAX2 is detected in the Mü llerian ducts and its derivatives in mice. 18 However, information on the function and the clinical significance of PAX2 in the human Mü llerian system is sparse 19,20 in contrast to what is known about its role in renal development.…”

mentioning

confidence: 99%

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

et al. 2007

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PAX2 is a urogenital developmental transcription factor expressed in the Wolffian ducts, developing kidneys, and Mü llerian ducts during embryonic stage. Its function in renal development is well documented and its clinical application in the diagnosis of lesions of renal origin has been reported recently. However, information on its role in the Mü llerian-derived genital tract is sparse. In this study, we investigated the expression of PAX2 in human female genital tract using immunohistochemistry. We demonstrated that PAX2 was expressed specifically in the epithelial cells of fallopian tube, endometrial and endocervical glands, but not in the stromal tissues in these areas. PAX2 was detected in secondary Mü llerian structures in the ovary, such as endometriotic and endosalpingiotic glands and rete ovarii, but not in ovarian surface epithelium, surface epithelium-derived inclusion cysts, stroma, or sex-cord-derived structures such as follicles, oocytes, and corpus luteum. In addition, PAX2 was detected in 67% of ovarian papillary serous carcinomas (N ¼ 36) but rarely in peritoneal malignant mesotheliomas, with two exceptions (N ¼ 54). Interestingly, the two PAX2-positive 'peritoneal malignant mesotheliomas' were from female patients and were positive for estrogen receptor. The significance of expression of PAX2 and estrogen receptor in these cases is under investigation. Taken together, we suggest that PAX2 is a novel Mü llerian-specific epithelial marker when used in proper clinical settings. Identification of PAX2 in the majority of papillary serous carcinomas of the ovary but not in the ovarian surface epithelium or epithelium-derived inclusion cysts suggests that this malignant epithelial tumor may be directly derived from the primary or secondary Mü llerian epithelium in or surrounding the ovary, rather than from the surface epithelium or its derivatives.

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PAX-2: A Developmental Gene Constitutively Expressed in the Mouse Epididymis and Ductus Deferens

Abstract: Pax-2 is a transcriptional regulator expressed in the epithelium of the ductus deferens and epididymis and may be a regulator of epithelial genes involved in sperm maturation and support.

Cited by 22 publications

References 16 publications

Spatiotemporal expression of Pax genes in amphioxus: Insights into Pax-related organogenesis and evolution

Spatiotemporal expression of Pax genes in amphioxus: Insights into Pax-related organogenesis and evolution

The Coming of Age of the Epididymis

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

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